莫克雌醇
外观
![]() | |
![]() | |
临床资料 | |
---|---|
商品名 | Surestryl |
其他名称 | R-2858, RU-2858, NSC-118191; 11β-Methoxy-17α-ethynylestradiol; 11β-MeO-EE 11β-Methoxy-17α-ethynylestra-1,3,5(10)-triene-3,17β-diol |
怀孕分级 |
|
给药途径 | 口服 |
药物类别 | Estrogen; Estrogen ether |
ATC码 | |
法律规范状态 | |
法律规范 |
|
药物动力学数据 | |
生物利用度 | 33%[1] |
血浆蛋白结合率 | Minimal[1] |
药物代谢 | Liver[2] |
生物半衰期 | 8.2 hours[1] |
识别信息 | |
| |
CAS号 | 34816-55-2 ![]() |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C21H26O3 |
摩尔质量 | 326.44 g·mol−1 |
3D模型(JSmol) | |
| |
|
莫克雌醇(英语:Moxestrol)是一种雌激素类药物,商品名Surestryl,化学名为11β-甲氧基乙炔雌二醇,与RU-16117是11β-差向异构体,用于治疗更年期综合症和月经失调,在欧洲有上市销售[3][4][2][5][6]。
参考资料
[编辑]- ^ 1.0 1.1 1.2 Salmon, J.; Coussediere, D.; Cousty, C.; Raynaud, J.P. Pharmacokinetics and metabolism of moxestrol in animals—rat, dog and monkey. Journal of Steroid Biochemistry. 1983, 19 (2): 1223–1234. ISSN 0022-4731. PMID 6887930. doi:10.1016/0022-4731(83)90421-1.
- ^ 2.0 2.1 Jonathan J. Li; Satyabrata Nandi; Sara A. Li. Hormonal Carcinogenesis: Proceedings of the First International Symposium. Springer Science & Business Media. 6 December 2012: 184– [2021-11-30]. ISBN 978-1-4613-9208-8. (原始内容存档于2021-11-30).
- ^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 841– [2021-11-30]. ISBN 978-1-4757-2085-3. (原始内容存档于2021-11-30).
- ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 186– [2021-11-30]. ISBN 978-0-7514-0499-9. (原始内容存档于2021-11-30).
- ^ Adrain D. Nunn. Radiopharmaceuticals: Chemistry and Pharmacology. CRC Press. 19 June 1992: 342– [2021-11-30]. ISBN 978-0-8247-8624-3. (原始内容存档于2021-11-30).
- ^ William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences. The Extra Pharmacopoeia. Pharmaceutical Press. 1993: 1188 [2021-11-30]. ISBN 978-0-85369-300-0. (原始内容存档于2021-11-30).
Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general. Moxestrol is reponed to have a prolonged duration of action. It has been given by mouth in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 µg weekly for long-term therapy to 25 to 250 µg daily for short-term use.