EGR4

早期生长应答蛋白4; Early growth response 4
标识
代号	EGR4; NGFI-C; NGFIC; PAT133
扩展标识	遗传学：128992 鼠基因：99252 同源基因：1485 GeneCards: EGR4 Gene
基因本体论描述
分子功能	· DNA binding; · sequence-specific DNA binding transcription factor activity; · zinc ion binding;
细胞成分	· nucleus;
生物过程	· transcription, DNA-dependent; · positive regulation of cell proliferation;
	Sources: Amigo / QuickGO
直系同源体
	查; 论; 编;

早期生长反应蛋白4（英语：Early growth response protein 4，EGR-4），也被称为AT133，是一个由人类基因EGR4编码的蛋白质^[1]。

EGR-4是一种锌指结构转录因子早期生长反应蛋白家族（EGF）的一员

参考文献[编辑]

^ Entrez Gene: early growth response 4. （原始内容存档于2019-10-16）.

延伸阅读[编辑]

Crosby SD, Veile RA, Donis-Keller H; et al. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C.. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (10): 4739–43. PMID 1584812. doi:10.1073/pnas.89.10.4739.
Hillier LW, Graves TA, Fulton RS; et al. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature. 2005, 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
Müller HJ, Skerka C, Bialonski A, Zipfel PF. Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. Proc. Natl. Acad. Sci. U.S.A. November 1991, 88 (22): 10079–83. PMC 52871 . PMID 1658795. doi:10.1073/pnas.88.22.10079.
Decker EL, Nehmann N, Kampen E; et al. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.. Nucleic Acids Res. 2003, 31 (3): 911–21. PMC 149206 . PMID 12560487. doi:10.1093/nar/gkg186.
Liu BC, Zhang J, Wang L; et al. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population.. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2010, 34 (3): 506–9. PMID 20144677. doi:10.1016/j.pnpbp.2010.02.005.
Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Holst C, Skerka C, Lichter P; et al. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133.. Hum. Mol. Genet. 1993, 2 (4): 367–72. PMID 8504297. doi:10.1093/hmg/2.4.367.
Crosby SD, Puetz JJ, Simburger KS; et al. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.. Mol. Cell. Biol. 1991, 11 (8): 3835–41. PMC 361165 . PMID 2072895.
Hadziselimovic F, Hadziselimovic NO, Demougin P; et al. EGR4 is a master gene responsible for fertility in cryptorchidism.. Sex Dev. 2009, 3 (5): 253–63. PMID 19828938. doi:10.1159/000249147.

[entrez-1] Entrez Gene: early growth response 4. （原始内容存档于2019-10-16）.

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