GRIA1

GRIA1
识别号
别名	GRIA1；, GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate ionotropic receptor AMPA type subunit 1, Glutamate receptor, ionotropic, AMPA 1
外部ID	OMIM：138248 MGI：95808 HomoloGene：20226 GeneCards：GRIA1
相关疾病
	肥胖症
为以下药物的标靶
	(S)-AMPA、茴拉西坦、cx516、CX546、环噻嗪、IDRA-21、吡拉西坦、S-18986、LY-300168、GYKI-2466、NBQX、tezampanel、argiotoxin、Joro toxin、dasolampanel、Irampanel、selurampanel、zonampanel、托吡酯
基因位置（人类）
染色体	5号染色体
终止	153,813,869 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	57,221,070 bp
基因本体
分子功能	• glutamate receptor activity; • PDZ domain binding; • AMPA glutamate receptor activity; • ion channel activity; • 血浆蛋白结合; • ionotropic glutamate receptor activity; • extracellularly glutamate-gated ion channel activity; • excitatory extracellular ligand-gated ion channel activity; • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; • amyloid-beta binding; • signaling receptor activity;
细胞组分	• integral component of membrane; • recycling endosome; • endocytic vesicle membrane; • postsynaptic membrane; • cell projection; • endoplasmic reticulum membrane; • 膜; • 突触小泡; • 突触后致密物质; • axonal spine; • 细胞膜; • 树突棘; • 突触; • dendrite membrane; • cell surface; • 细胞连接; • neuronal cell body; • 树突; • 内质网; • dendritic spine membrane; • neuron spine; • ER to Golgi transport vesicle membrane; • neuron projection; • AMPA glutamate receptor complex; • ionotropic glutamate receptor complex; • endoplasmic reticulum-Golgi intermediate compartment membrane; • Golgi membrane; • postsynapse; • postsynaptic density membrane; • 核内体; • early endosome membrane; • somatodendritic compartment; • recycling endosome membrane; • synaptic membrane; • glutamatergic synapse; • integral component of postsynaptic density membrane;
生物学过程	• receptor internalization; • ion transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • ion transmembrane transport; • COPII vesicle coating; • 长期记忆; • transport; • 长期抑制作用; • 信号转导; • 化学性突触传递; • ionotropic glutamate receptor signaling pathway; • 兴奋性动作电位; • 突触后电位; • regulation of postsynaptic cytosolic calcium ion concentration; • chemical synaptic transmission, postsynaptic; • regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
直系同源
	2890
	14799
	ENSG00000155511
	ENSMUSG00000020524
	P42261
	P23818
NM_000827; NM_001114183; NM_001258019; NM_001258020; NM_001258021;
	NM_001258022; NM_001258023; NM_001364165; NM_001364166; NM_001364167
	NM_001113325; NM_001252403; NM_008165
NP_000818; NP_001107655; NP_001244948; NP_001244949; NP_001244950;
	NP_001244951; NP_001244952; NP_001351094; NP_001351095; NP_001351096
	NP_001106796; NP_001239332; NP_032191
	维基数据
查看/编辑人类	查看/编辑小鼠

GRIA1(英语：glutamate receptor, ionotropic, AMPA 1)是由GRIA1 基因编码的蛋白质。^[7]^[8]

交互作用[编辑]

GRIA1与以下蛋白质有交互作用:

DLG1（英语：DLG1）^[9]^[10]^[11]
EPB41L2（英语：EPB41L2）,^[12]
GRID2（英语：GRID2）.^[13]

参见[编辑]

AMPA受体（英语：AMPA receptor）

参考[编辑]

^ 與GRIA1相關的疾病；在維基數據上查看/編輯參考.
^ 對GRIA1起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000155511 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000020524 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc Natl Acad Sci U S A. October 1991, 88 (17): 7557–61. PMC 52340 . PMID 1652753. doi:10.1073/pnas.88.17.7557.
^ McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF. Chromosomal localization of human glutamate receptor genes. J Neurosci. July 1992, 12 (7): 2555–62. PMID 1319477.
^ Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J. Biol. Chem. November 2003, 278 (45): 44745–52. PMID 12933808. doi:10.1074/jbc.M303576200.
^ Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J. Biol. Chem. July 1998, 273 (31): 19518–24. PMID 9677374. doi:10.1074/jbc.273.31.19518.
^ Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J. Neurosci. October 2001, 21 (19): 7506–16. PMID 11567040.
^ Shen L, Liang F, Walensky LD, Huganir RL. Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J. Neurosci. November 2000, 20 (21): 7932–40. PMID 11050113.
^ Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M. Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. Brain Res. Mol. Brain Res. January 2003, 110 (1): 27–37. PMID 12573530. doi:10.1016/s0169-328x(02)00561-2.

深入阅读[编辑]

Sun W, Ferrer-Montiel AV, Schinder AF, McPherson JP, Evans GA, Montal M. Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (4): 1443–7. PMC 48467 . PMID 1311100. doi:10.1073/pnas.89.4.1443.
Potier MC, Spillantini MG, Carter NP. The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5.. DNA Seq. 1992, 2 (4): 211–8. PMID 1320959. doi:10.3109/10425179209020805.
Yakel JL, Vissavajjhala P, Derkach VA, Brickey DA, Soderling TR. Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (5): 1376–80. PMC 42522 . PMID 7877986. doi:10.1073/pnas.92.5.1376.
Eastwood SL, Burnet PW, Beckwith J, Kerwin RW, Harrison PJ. AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus.. NeuroReport. 1994, 5 (11): 1325–8. PMID 7919190. doi:10.1097/00001756-199406270-00007.
Roche KW, Raymond LA, Blackstone C, Huganir RL. Transmembrane topology of the glutamate receptor subunit GluR6.. J. Biol. Chem. 1994, 269 (16): 11679–82. PMID 8163463.
McLaughlin DP, Cheetham ME, Kerwin RW. Expression of alternatively-spliced glutamate receptors in human hippocampus.. Eur. J. Pharmacol. 1993, 244 (1): 89–92. PMID 8420792. doi:10.1016/0922-4106(93)90062-E.
Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit.. Neuron. 1996, 16 (6): 1179–88. PMID 8663994. doi:10.1016/S0896-6273(00)80144-0.
Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. Homer: a protein that selectively binds metabotropic glutamate receptors.. Nature. 1997, 386 (6622): 284–8. PMID 9069287. doi:10.1038/386284a0.
Barria A, Derkach V, Soderling T. Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor.. J. Biol. Chem. 1998, 272 (52): 32727–30. PMID 9407043. doi:10.1074/jbc.272.52.32727.
Ripellino JA, Neve RL, Howe JR. Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.. Neuroscience. 1998, 82 (2): 485–97. PMID 9466455. doi:10.1016/S0306-4522(97)00296-0.
Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit.. J. Biol. Chem. 1998, 273 (31): 19518–24. PMID 9677374. doi:10.1074/jbc.273.31.19518.
Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.. Neuron. 1998, 21 (4): 707–16. PMID 9808458. doi:10.1016/S0896-6273(00)80588-7.
Montague AA, Greer CA. Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb.. J. Comp. Neurol. 1999, 405 (2): 233–46. PMID 10023812. doi:10.1002/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A.
Leuschner WD, Hoch W. Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains.. J. Biol. Chem. 1999, 274 (24): 16907–16. PMID 10358037. doi:10.1074/jbc.274.24.16907.
Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.. Science. 1999, 284 (5421): 1811–6. PMID 10364548. doi:10.1126/science.284.5421.1811.
Rubio ME, Wenthold RJ. Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors.. J. Neurochem. 1999, 73 (3): 942–8. PMID 10461883. doi:10.1046/j.1471-4159.1999.0730942.x.
Stinehelfer S, Vruwink M, Burette A. Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex.. Brain Res. 2000, 861 (1): 37–44. PMID 10751563. doi:10.1016/S0006-8993(00)01952-1.

外部链接[编辑]

医学主题词表（MeSH）：GRIA1+protein,+human

GRIA1引用了美国国家医学图书馆提供的数据，这些数据属于公共领域。

[1] 與GRIA1相關的疾病；在維基數據上查看/編輯參考.

[2] 對GRIA1起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000155511 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000020524 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1652753-7] Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc Natl Acad Sci U S A. October 1991, 88 (17): 7557–61. PMC 52340 . PMID 1652753. doi:10.1073/pnas.88.17.7557.

[pmid1319477-8] McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF. Chromosomal localization of human glutamate receptor genes. J Neurosci. July 1992, 12 (7): 2555–62. PMID 1319477.

[pmid12933808-9] Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J. Biol. Chem. November 2003, 278 (45): 44745–52. PMID 12933808. doi:10.1074/jbc.M303576200.

[pmid9677374-10] Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J. Biol. Chem. July 1998, 273 (31): 19518–24. PMID 9677374. doi:10.1074/jbc.273.31.19518.

[pmid11567040-11] Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J. Neurosci. October 2001, 21 (19): 7506–16. PMID 11567040.

[pmid11050113-12] Shen L, Liang F, Walensky LD, Huganir RL. Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J. Neurosci. November 2000, 20 (21): 7932–40. PMID 11050113.

[pmid12573530-13] Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M. Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. Brain Res. Mol. Brain Res. January 2003, 110 (1): 27–37. PMID 12573530. doi:10.1016/s0169-328x(02)00561-2.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]