Ras超家族

现有可用的蛋白结构：
Pfam	结构（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	结构概要
PDB	2folA:13-174 1ukvY:10-171 1yznA:10-171 2bcgY:10-171 3rabA:24-185 1x3sA:10-171 2bmdA:10-171 1z0fA:13-174 1oivB:13-172 1oiwA:13-172 1z0dC:23-183 1n6rA:22-183 1z0jA:7-168 1yztB:21-182 1yzqA:15-176 1vg8D:10-175 1vg0B:10-175 1yzlA:9-174 2f7sA:11-183 1plj :5-165 821p :5-165 1x1sA:15-177 1u8zA:16-177 2bovA:16-177 1kao :5-166 1guaA:5-167 1xtsA:8-169 1kmqA:7-180 1m7bA:25-199 3ranA:12-170 1g17B:22-182 1g16C:22-182 1zbdA:24-185 2ew1A:11-172 1z0kA:10-171 2bmeA:10-171 1yu9A:10-171 2aedA:13-174 1z0aD:8-169 2a5jA:8-169 1yzkA:13-174 1oixA:13-172 1z06A:35-201 1huqA:23-182 1z07A:23-182 1r2qA:22-183 1ek0A:9-173 1yvdA:7-168 2fg5A:7-168 1z08A:21-182 1yzuB:21-182 1z0iA:21-182 1d5cA:13-172 1t91C:10-175 1vg9H:10-175 1vg1A:10-175 1ky3A:10-178 1ky2A:10-178 1wmsB:9-174 1s8fB:9-174 1z22A:11-171 1z2aA:11-171 1ctqA:5-165 1crp :5-165 2eryB:16-177 2fn4A:31-192 1x1rA:15-177 1u90A:16-177 1u8yB:16-177 1uadB:16-177 2a78A:16-177 3rapR:5-166 2rap :5-166 1c1yA:5-167 1xtrA:8-169 1xtqA:8-169 2erxB:9-171 1a4rB:5-178 1tx4B:7-179 1cxzA:7-180 1gwnA:25-199 2bkuA:12-170 1qg4B:12-170 1byuA:12-170 2atvA:8-169

	H-Ras在PDB121p上的结构，颜色代表了Pfam宗系上的氨基酸保守性数据，金色：最保守；深青色：最不保守
鉴定
标志	Ras
Pfam	PF00071（旧版）
InterPro（英语：InterPro）	IPR013753
PROSITE（英语：PROSITE）	PDOC00017
SCOP（英语：Structural Classification of Proteins）	5p21 / SUPFAM
OPM（英语：Orientations of Proteins in Membranes database）蛋白	1uad
CDD（英语：Conserved Domain Database）	cd00882
现有可用的蛋白结构：
Pfam	结构（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	结构概要
PDB	2folA:13-174 1ukvY:10-171 1yznA:10-171 2bcgY:10-171 3rabA:24-185 1x3sA:10-171 2bmdA:10-171 1z0fA:13-174 1oivB:13-172 1oiwA:13-172 1z0dC:23-183 1n6rA:22-183 1z0jA:7-168 1yztB:21-182 1yzqA:15-176 1vg8D:10-175 1vg0B:10-175 1yzlA:9-174 2f7sA:11-183 1plj :5-165 821p :5-165 1x1sA:15-177 1u8zA:16-177 2bovA:16-177 1kao :5-166 1guaA:5-167 1xtsA:8-169 1kmqA:7-180 1m7bA:25-199 3ranA:12-170 1g17B:22-182 1g16C:22-182 1zbdA:24-185 2ew1A:11-172 1z0kA:10-171 2bmeA:10-171 1yu9A:10-171 2aedA:13-174 1z0aD:8-169 2a5jA:8-169 1yzkA:13-174 1oixA:13-172 1z06A:35-201 1huqA:23-182 1z07A:23-182 1r2qA:22-183 1ek0A:9-173 1yvdA:7-168 2fg5A:7-168 1z08A:21-182 1yzuB:21-182 1z0iA:21-182 1d5cA:13-172 1t91C:10-175 1vg9H:10-175 1vg1A:10-175 1ky3A:10-178 1ky2A:10-178 1wmsB:9-174 1s8fB:9-174 1z22A:11-171 1z2aA:11-171 1ctqA:5-165 1crp :5-165 2eryB:16-177 2fn4A:31-192 1x1rA:15-177 1u90A:16-177 1u8yB:16-177 1uadB:16-177 2a78A:16-177 3rapR:5-166 2rap :5-166 1c1yA:5-167 1xtrA:8-169 1xtqA:8-169 2erxB:9-171 1a4rB:5-178 1tx4B:7-179 1cxzA:7-180 1gwnA:25-199 2bkuA:12-170 1qg4B:12-170 1byuA:12-170 2atvA:8-169

Ras超家族（英语：Ras superfamily）是一个小GTP酶（英语：small GTPase）蛋白质超家族，名称来自其中的Ras亚家族（在人类中为KRAS、NRAS和HRAS）。

Ras超家族中有超过100种蛋白质^[1] ，根据其序列、结构和功能，可分为9个主要的家族，各自还可再分亚家族。这9个蛋白质家族为：Ras、Rad、Rab、Rap、Ran、Rho、Rheb、Rit和Arf，Miro最近也被列入这个超家族中。

每个亚家族都有共同的G结构域核心，提供GTP酶与GTP/GDP交换活性。

周围序列有助于确定小GTP酶的功能特异性，例如Rho亚家族常见的“插入环”，特别有助于与效应蛋白如IQGAP和WASP(Wiskott–Aldrich syndrome protein)结合。

通常，Ras家族负责细胞增殖：Rho用于细胞形态，Ran用于核运输，Rab和Arf用于囊泡运输^[2]。

亚家族与其成员[编辑]

以下列表列出了人类蛋白质中Ras超家族的成员^[1]：

亚家族	功能	成员
Ras	细胞增殖 ^[2]	DIRAS1; DIRAS2; DIRAS3; ERAS; GEM; HRAS; KRAS; MRAS; NKIRAS1; NKIRAS2; NRAS; RALA; RALB; RAP1A; RAP1B; RAP2A; RAP2B; RAP2C; RASD1; RASD2; RASL10A; RASL10B; RASL11A; RASL11B; RASL12; REM1; REM2; RERG; RERGL; RRAD; RRAS; RRAS2
Rho	细胞骨架的动力与形态^[2]	RHOA; RHOB; RHOBTB1; RHOBTB2; RHOBTB3; RHOC; RHOD; RHOF; RHOG; RHOH; RHOJ; RHOQ; RHOU; RHOV; RND1; RND2; RND3; RAC1; RAC2; RAC3; CDC42
Rab	膜转运	RAB1A; RAB1B; RAB2; RAB3A; RAB3B; RAB3C; RAB3D; RAB4A; RAB4B; RAB5A; RAB5B; RAB5C; RAB6A; RAB6B; RAB6C; RAB7A; RAB7B; RAB7L1; RAB8A; RAB8B; RAB9; RAB9B; RABL2A; RABL2B; RABL4; RAB10; RAB11A; RAB11B; RAB12; RAB13; RAB14; RAB15; RAB17; RAB18; RAB19; RAB20; RAB21; RAB22A; RAB23; RAB24; RAB25; RAB26; RAB27A; RAB27B; RAB28; RAB2B; RAB30; RAB31; RAB32; RAB33A; RAB33B; RAB34; RAB35; RAB36; RAB37; RAB38; RAB39; RAB39B; RAB40A; RAB40AL; RAB40B; RAB40C; RAB41; RAB42; RAB43
Rap	细胞粘附（英语：cell adhesion）	RAP1A; RAP1B; RAP2A; RAP2B; RAP2C
Arf	囊泡转运（英语：Vesicular transport protein）^[2]	ARF1; ARF3; ARF4; ARF5; ARF6; ARL1; ARL2; ARL3; ARL4; ARL5; ARL5C; ARL6; ARL7; ARL8; ARL9; ARL10A; ARL10B; ARL10C; ARL11; ARL13A; ARL13B; ARL14; ARL15; ARL16; ARL17; TRIM23, ARL4D; ARFRP1; ARL13B
Ran	核运输	RAN
Rheb	mTOR途径	RHEB; RHEBL1
RGK		RRAD; GEM; REM; REM2
Rit		RIT1; RIT2
Miro	线粒体转运	RHOT1; RHOT2

未分类：

参考文献[编辑]

^ ^1.0 ^1.1 Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J. Cell. Sci. March 2005, 118 (Pt 5): 843–6. PMID 15731001. doi:10.1242/jcs.01660.
^ ^2.0 ^2.1 ^2.2 ^2.3 Munemitsu S, Innis M, Clark R, McCormick F, Ullrich A, Polakis P. Molecular cloning and experssion of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 1990, 10 (11): 5977–82. ISSN 0270-7306. PMC 361395 . PMID 2122236.

[pmid15731001-1] 1.0 ^1.1 Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J. Cell. Sci. March 2005, 118 (Pt 5): 843–6. PMID 15731001. doi:10.1242/jcs.01660.

[Munemitsu-2] 2.0 ^2.1 ^2.2 ^2.3 Munemitsu S, Innis M, Clark R, McCormick F, Ullrich A, Polakis P. Molecular cloning and experssion of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 1990, 10 (11): 5977–82. ISSN 0270-7306. PMC 361395 . PMID 2122236.

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