鄰苯二甲酸二甲酯
外觀
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鄰苯二甲酸二甲酯[1][2]pl | |
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別名 | Dimethyl phthalate |
識別 | |
CAS號 | 131-11-3 ![]() |
PubChem | 8554 |
ChemSpider | 13837329 |
SMILES |
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InChI |
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InChIKey | NIQCNGHVCWTJSM-UHFFFAOYAF |
KEGG | C11233 |
性質 | |
化學式 | C10H10O4 |
摩爾質量 | 194.184 g/mol g·mol⁻¹ |
外觀 | Colorless oily liquid |
氣味 | slight aromatic odor[2] |
密度 | 1.19 g/cm3 |
熔點 | 2 °C(275 K) |
沸點 | 283 - 284 °C(272 K) |
溶解性(水) | 0.4% (20°C)[2] |
蒸氣壓 | 0.01 mmHg (20°C)[2] |
藥理學 | |
ATC代碼 | P03BX02(P03),QP53 |
危險性 | |
爆炸極限 | 0.9%-?[2] |
PEL | TWA 5 mg/m3[2] |
致死量或濃度: | |
LD50(中位劑量)
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6900 mg/kg (rat, oral) 1000 mg/kg (rabbit, oral) 2400 mg/kg (guinea pig, oral) 6800 mg/kg (rat, oral) 6800 mg/kg (mouse, oral) 4400 mg/kg (rabbit, oral) 2400 mg/kg (guinea pig, oral)[3] |
LCLo(最低)
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9630 mg/m3[3] |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
鄰苯二甲酸二甲酯(英語:Dimethyl phthalate,簡稱DMP),是一種有機化合物暨鄰苯二甲酸酯。它是無色油狀液體,可溶於有機溶劑,[4]但難容於水(~4 g/L)。
鄰苯二甲酸二甲酯具有多種用途,其中最常用於驅蟲劑或殺外寄生蟲藥,例如飼養牲畜時防範蚊子和蒼蠅。[4]短鏈或低分子量鄰苯二甲酸酯也經常用於化妝品、墨水、肥皂、家用清潔用品等消費性產品中。[5]DMP的其他用途包括固體火箭推進劑和塑料。[4][5]
美國環境保護署已將鄰苯二甲酸二甲酯列為「不可歸類的人類致癌物」。[6][7]在毒性方面,它的口服LD50在大鼠為4390至8200毫克/公斤體重/天,皮下注射LD50在大鼠為38000毫克/公斤體重,而在豚鼠則超過4800毫克/公斤體重。[8]
參考資料
[編輯]- ^ Dimethyl phthlate (頁面存檔備份,存於網際網路檔案館) at chemicalland21.com
- ^ 2.0 2.1 2.2 2.3 2.4 2.5 NIOSH Pocket Guide to Chemical Hazards. #0228. NIOSH.
- ^ 3.0 3.1 Dimethylphthalate. Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
- ^ 4.0 4.1 4.2 Carlson KR, Patton LE. Toxicity Review for Dimethyl Phthalate (DMP, CASRN 131-11-3) (PDF) (報告). U.S Consumer Product Safety Commission. [2022-12-29]. (原始內容存檔 (PDF)於2023-01-18).
- ^ 5.0 5.1 Schettler T. Human exposure to phthalates via consumer products. International Journal of Andrology. February 2006, 29 (1): 134–139; discussion 181–185. PMID 16466533. doi:10.1111/j.1365-2605.2005.00567.x.
- ^ Phillips L. EPA's Exposure Assessment Toolbox (EPA-Expo-Box). Journal of Environmental Informatics. June 2015, 25 (2): 81–84. ISSN 1726-2135. S2CID 113872276. doi:10.3808/jei.201400269.
- ^ Newburg-Rinn SD. Commentary: Activities of the Environmental Protection Agency concerning Phthalate Esters. Environmental Health Perspectives. November 1982, 45: 137–139. ISSN 0091-6765. JSTOR 3429398. doi:10.2307/3429398.
- ^ National Industrial Chemicals Notification and Assessment Scheme (NICNAS); Australia Government. Dimethyl Phthalate (PDF). Existing Chemical Hazard Assessment Report. June 2008 [2022-12-29]. (原始內容存檔 (PDF)於2022-12-29).