前列腺素D₂

前列腺素D2
	IUPAC名; 9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
識別
CAS號	41598-07-6
PubChem	448457
SMILES	CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O;
ChEBI	15555
MeSH	Prostaglandin+D2
IUPHAR配體	1891
性質
化學式	C20H32O5
摩爾質量	352.465 g/mol g·mol⁻¹
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

前列腺素D₂（PGD₂）是前列腺素的一種。^[1]^[2] 哺乳動物體內，大量的前列腺素只存在於腦部和肥大細胞中，其會影響過敏性疾病如哮喘等的發展。

前列腺素D₂的研究始於1989年，當時發現其為攝取煙酸後血管舒張（煙堿酸潮紅）的原發性介質。^[3] 2012年發現局部的PGD₂提高會抑制頭髮生長，^[4] 研究指出這一現象與一個叫做GPR44的受體有關，後者因此成為了治療雄激素性脫髮的藥物作用靶點，因此數種使用PGD₂的哮喘藥都開始尋求減少其用量的方法。^[5]

參考文獻[編輯]

^ Saito S, Tsuda H, Michimata T. Prostaglandin D2 and reproduction. American Journal of Reproductive Immunology (New York, N.Y. : 1989). May 2002, 47 (5): 295–302 [2011-04-09]. PMID 12148545. doi:10.1034/j.1600-0897.2002.01113.x （美國英語）.
^ Pettipher R, Hansel TT. Antagonists of the prostaglandin D2 receptor CRTH2. Drug News & Perspectives. 2008, 21 (6): 317–22 [2011-04-09]. PMID 18836589. doi:10.1358/dnp.2008.21.6.1246831. （原始內容存檔於2021-01-25）（美國英語）.
^ Morrow, JD; Parsons Wg, 3rd; Roberts Lj, 2nd. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. August 1989, 38 (2): 263–74. PMID 2475889.
^ Garza, Luis A.,; et al. Prostaglandin D₂ Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia. Science Translational Medicine. 2012-03-21, 4 (126): 126ra34–126ra34 [2012-03-22]. ISSN 1946-6234. PMC 3319975 . PMID 22440736. doi:10.1126/scitranslmed.3003122. （原始內容存檔於2020-11-18）.
^ Clues to the cause of male pattern baldness. Nature magazine (News and Comments). [2014-05-02]. （原始內容存檔於2020-11-12）.

[pmid12148545-1] Saito S, Tsuda H, Michimata T. Prostaglandin D2 and reproduction. American Journal of Reproductive Immunology (New York, N.Y. : 1989). May 2002, 47 (5): 295–302 [2011-04-09]. PMID 12148545. doi:10.1034/j.1600-0897.2002.01113.x （美國英語）.

[pmid18836589-2] Pettipher R, Hansel TT. Antagonists of the prostaglandin D2 receptor CRTH2. Drug News & Perspectives. 2008, 21 (6): 317–22 [2011-04-09]. PMID 18836589. doi:10.1358/dnp.2008.21.6.1246831. （原始內容存檔於2021-01-25）（美國英語）.

[3] Morrow, JD; Parsons Wg, 3rd; Roberts Lj, 2nd. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. August 1989, 38 (2): 263–74. PMID 2475889.

[Garza_et_al_2012-4] Garza, Luis A.,; et al. Prostaglandin D₂ Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia. Science Translational Medicine. 2012-03-21, 4 (126): 126ra34–126ra34 [2012-03-22]. ISSN 1946-6234. PMC 3319975 . PMID 22440736. doi:10.1126/scitranslmed.3003122. （原始內容存檔於2020-11-18）.

[garza_nature_article-5] Clues to the cause of male pattern baldness. Nature magazine (News and Comments). [2014-05-02]. （原始內容存檔於2020-11-12）.

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