衛生假說

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衛生假說英語:hygiene hypothesis)是一種醫學假說,指童年時因缺少接觸傳染源、共生微生物(如胃腸道菌群益生菌)與寄生物,從而抑制了免疫系統的正常發展,進而增加了感染過敏性疾病的可能性。[1]發達國家青少年自身免疫性疾病急性淋巴性白血病發病率的增加被認為與衛生假說有關。[2][3]一些證據表明自閉症是由免疫疾病導致的[4][5][6][7][8],有一項研究便支持衛生假說,認為這是導致自閉症的原因之一。[9]

參考文獻[編輯]

  1. ^ Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax. 55. August 2000,. Suppl 1 (90001): S2–10. PMC 1765943. PMID 10943631. doi:10.1136/thorax.55.suppl_1.S2. 
  2. ^ Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions. Smith MA, Simon R, Strickler HD, McQuillan G, Ries LA, Linet MS.National Cancer Institute, Division of Cancer Treatment and Diagnosis, Bethesda, MD 20892, USA.
  3. ^ The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Okada H, Kuhn C, Feillet H, Bach JF. INSERM U1013, Necker-Enfants Malades Hospital, Paris, France.
  4. ^ Croonenberghs J, Wauters A, Devreese K; 等. Increased serum albumin, gamma globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Psychol Med. 2002, 32 (8): 1457–63. PMID 12455944. 
  5. ^ Gupta S, Aggarwal S, Rashanravan B, Lee T. Th1- and Th2- like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol 1998;85(1):106–9.
  6. ^ Ashwood P, Wakefield AJ. Immune activation of peripheral blood and mucosal CD3(+) lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. JNeuroimmunol 2006;173(1–2):126–34.
  7. ^ Zimmerman AW, Jyonouchi H, Comi AM; 等. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol. 2005, 33 (3): 195–201. PMID 16139734. doi:10.1016/j.pediatrneurol.2005.03.014. 
  8. ^ Molloy CA, Morrow AL, Meinzen-Derr J; 等. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol. 2006, 172 (1–2): 198–205. PMID 16360218. doi:10.1016/j.jneuroim.2005.11.007. 
  9. ^ "Autism, asthma, inflammation, and the hygiene hypothesis 互聯網檔案館存檔,存檔日期2012-01-05.", Kevin G. Becker Gene Expression and Genomics Unit, RRB, TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Room 208, 333 Cassell Drive, Baltimore, MD 21224, United States .