KLF4：修订间差异
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Kruppel样因子4（{{lang-en|Kruppel-like factor 4，KLF4}}）或肠富集Krüppel样因子（{{lang-en|gut-enriched Krüppel-like factor，GKLF}}）是[[锌指]][[转录因子]]KLF家族的一个成员，后者属于一个较大的{{tsl|en|Sp1 transcription factor|SP1}}样转录因子家族<ref>{{cite journal | vauthors = Black AR, Black JD, Azizkhan-Clifford J | title = Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer | journal = Journal of Cellular Physiology | volume = 188 | issue = 2 | pages = 143–60 | date = August 2001 | pmid = 11424081 | doi = 10.1002/jcp.1111 | s2cid = 39150180 | doi-access = free }}</ref><ref name="pmid11137451">{{cite journal | vauthors = Dang DT, Pevsner J, Yang VW | title = The biology of the mammalian Krüppel-like family of transcription factors | journal = The International Journal of Biochemistry & Cell Biology | volume = 32 | issue = 11–12 | pages = 1103–21 | date = November 2000 | pmid = 11137451 | doi=10.1016/s1357-2725(00)00059-5 | pmc=2754176}}</ref><ref>{{cite journal | vauthors = Kaczynski J, Cook T, Urrutia R | title = Sp1- and Krüppel-like transcription factors | journal = Genome Biology | volume = 4 | issue = 2 | pages = 206 | year = 2003 | pmid = 12620113 | pmc=151296 | doi=10.1186/gb-2003-4-2-206 }}</ref>。KLF4参与[[細胞增殖]]、[[细胞分化]]、[[细胞凋亡]]和[[体细胞]]{{tsl|en|Reprogramming|重编程}}的调节。有证据表明KLF4在包括[[大腸癌]]在内的一些癌症中是[[肿瘤抑制基因]]<ref>{{cite journal | vauthors = El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW | title = Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts | journal = Molecular Cancer | volume = 12 | pages = 89 | date = August 2013 | pmid = 23919723| doi = 10.1186/1476-4598-12-89 | pmc=3750599}}</ref>。与{{tsl|en|KLF2|KLF2}}类似，它在[[C端]]有三个C2H2-锌指<ref name="pmid11137451" />。它有两个[[核定位序列]]指引它定位于细胞核内<ref>{{cite journal | vauthors = Shields JM, Yang VW | title = Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins | journal = The Journal of Biological Chemistry | volume = 272 | issue = 29 | pages = 18504–7 | date = July 1997 | pmid = 9218496 | doi=10.1074/jbc.272.29.18504 | pmc=2268085}}</ref>。在[[胚胎幹細胞]](ESCs)和[[間充質幹細胞]](MSCs)中KLF4是显示多能化的很好标记。 |
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Kruppel样因子4（{{lang-en|Kruppel-like factor 4，KLF4}}）或肠富集Krüppel样因子（{{lang-en|gut-enriched Krüppel-like factor，GKLF}}）是[[锌指]][[转录因子]]KLF家族的一个成员，后者属于一个较大的{{tsl|en|Sp1 transcription factor|SP1}}样转录因子家族。KLF4参与[[細胞增殖]]、[[细胞分化]]、[[细胞凋亡]]和[[体细胞]]{{tsl|en|Reprogramming|重编程}}的调节。 |
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==参考== |
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[[Category:转录因子]] |
[[Category:转录因子]] |
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2021年5月24日 (一) 17:38的版本
Kruppel样因子4（英語：Kruppel-like factor 4，KLF4）或肠富集Krüppel样因子（英語：gut-enriched Krüppel-like factor，GKLF）是锌指转录因子KLF家族的一个成员，后者属于一个较大的SP1样转录因子家族[1][2][3]。KLF4参与細胞增殖、细胞分化、细胞凋亡和体细胞重编程的调节。有证据表明KLF4在包括大腸癌在内的一些癌症中是肿瘤抑制基因[4]。与KLF2类似，它在C端有三个C2H2-锌指[2]。它有两个核定位序列指引它定位于细胞核内[5]。在胚胎幹細胞(ESCs)和間充質幹細胞(MSCs)中KLF4是显示多能化的很好标记。
参考
- ^ Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. S2CID 39150180. doi:10.1002/jcp.1111
.
- ^ 2.0 2.1 Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176 . PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.
- ^ Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biology. 2003, 4 (2): 206. PMC 151296 . PMID 12620113. doi:10.1186/gb-2003-4-2-206.
- ^ El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Molecular Cancer. August 2013, 12: 89. PMC 3750599 . PMID 23919723. doi:10.1186/1476-4598-12-89.
- ^ Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085 . PMID 9218496. doi:10.1074/jbc.272.29.18504.
