核糖体结合糖蛋白

核糖体结合蛋白（英语：Ribophorin）是一种横跨膜糖蛋白，为粗糙内质网膜上寡聚糖转移酶的一个亚基。该蛋白分为核糖体结合蛋白I和核糖体结合蛋白II两种类型，对蛋白质的正确折叠有重要意义。它们在蛋白质复合物寡糖基转移酶（OST）中作为命名复合物的两个不同亚基起作用。核糖体结合蛋白I^[1]和II ^[2]仅存在于真核细胞中。

两种类型的核糖蛋白在核糖体与粗面内质网的结合以及依赖于这种相互作用的共翻译过程中发挥关键作用。粗面内质网的核糖蛋白含量等于核糖体单位的化学计量数。因此，这表明这些蛋白质在网状物中具有重要性，丰富性和良好的保存性。

参阅[编辑]

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参考资料[编辑]

^ Wilson CM, Kraft C, Duggan C, Ismail N, Crawshaw SG, High S. Ribophorin I associates with a subset of membrane proteins after their integration at the sec61 translocon. The Journal of Biological Chemistry. February 2005, 280 (6): 4195–206. PMID 15556939. doi:10.1074/jbc.M410329200.
^ Fu J, Pirozzi G, Sanjay A, et al. Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains. European Journal of Cell Biology. April 2000, 79 (4): 219–28. PMID 10826490. doi:10.1078/S0171-9335(04)70025-4.

[primera-1] Wilson CM, Kraft C, Duggan C, Ismail N, Crawshaw SG, High S. Ribophorin I associates with a subset of membrane proteins after their integration at the sec61 translocon. The Journal of Biological Chemistry. February 2005, 280 (6): 4195–206. PMID 15556939. doi:10.1074/jbc.M410329200.

[segona-2] Fu J, Pirozzi G, Sanjay A, et al. Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains. European Journal of Cell Biology. April 2000, 79 (4): 219–28. PMID 10826490. doi:10.1078/S0171-9335(04)70025-4.

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