副突变
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在表观遗传学中，副突变（paramutation）又称類突變，是单个基因座上两个等位基因之间的相互作用，其中一个等位基因诱导另一个等位基因发生可遗传变化；此为一種打破常規的遺傳模式。這種情況首先在玉米中發現，隨後在其他植物、真菌、甚至小鼠中發現[1]。而，用玉米所做的研究指出副突變是由RNA引導的[2]。
参考
[编辑]- ^ http://www.natureasia.com/taiwan/nature/updates/index.php?i=51984&issue=7100[永久失效連結]
- ^ http://www.biotech.org.cn/news/news/show.php?id=36660[永久失效連結]
文獻
[编辑]- BBC Science News - An easy to understand article involving paramutation （页面存档备份，存于互联网档案馆）
- Hollick JB, Dorweiler JE, Chandler VL. Paramutation and related allelic interactions (Review). Trends Genet. August 1997, 13 (8): 302–8 [2011-10-27]. PMID 9260515. doi:10.1016/S0168-9525(97)01184-0. （原始内容存档于2018-07-03）.
- Alleman M, Sidorenko L, McGinnis K; et al. An RNA-dependent RNA polymerase is required for paramutation in maize. Nature. July 2006, 442 (7100): 295–8. PMID 16855589. doi:10.1038/nature04884.
- Rassoulzadegan M, Grandjean V, Gounon P, Vincent S, Gillot I, Cuzin F. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature. May 2006, 441 (7092): 469–74. PMID 16724059. doi:10.1038/nature04674.
- Chandler VL, Stam M. Chromatin conversations: mechanisms and implications of paramutation. Nat. Rev. Genet. (Review). July 2004, 5 (7): 532–44. PMID 15211355. doi:10.1038/nrg1378.
- Stam M, Mittelsten Scheid O. Paramutation: an encounter leaving a lasting impression. Trends Plant Sci. June 2005, 10 (6): 283–90. PMID 15949762. doi:10.1016/j.tplants.2005.04.009.