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Rev响应元件：修订间差异

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The HIV-1 Rev response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs. In the presence of the HIV-1 accessory protein Rev, HIV-1 mRNAs that contain the RRE can be exported from the nucleus to the cytoplasm for downstream events such as translation and virion packaging.[1][2]

RRE and HIV-1 biology

Early phase

HIV-1 RNA export. In the early phase (top), transcribed viral RNAs (9kb) are spliced down to 2kb before export. One of these 2kb messages is translated to produce Rev which is then imported into the nucleus. In the late phase (bottom), Rev binds the RRE of newly transcribed RNAs before splicing and exports the unspliced (9kb) and partially spliced (4kb) messages to the cytoplasm. Translation of these messages produces late stage viral proteins. 9 kb messages can also serve as genomes for new virions.

另见

  • HIV Ribosomal frameshift signal
  • Retrovirus direct repeat 1 (dr1)

参考文献

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  2. ^ Pollard, Victoria W.; Malim, Michael H. The Hiv-1 Rev Protein. Annual Review of Microbiology. 1998, 52: 491–532. PMID 9891806. doi:10.1146/annurev.micro.52.1.491. 

延伸阅读

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外部链接

取自“https://zh.wikipedia.org/w/index.php?title=Rev响应元件&oldid=37687520”