耳垂摺痕：修订间差异
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'''耳垂摺痕'''（Earlobe crease），又稱作'''法蘭克徵象'''（Frank's sign），描述[[耳垂]]從[[耳屏]]延伸至[[耳廓]]後緣的對角線摺痕<ref name="Frank">{{cite journal |author=Frank ST |title=Aural sign of coronary-artery disease |journal=N. Engl. J. Med. |volume=289 |issue=6 |pages=327–8 |date=August 1973 |pmid=4718047 |doi= 10.1056/NEJM197308092890622|url=}}</ref><ref name=中醫 />。法蘭克徵象之名以{{tsl|en|Sanders T. Frank|桑德斯·T·法蘭克}}醫師之名命名<ref name="Frank"/>。 |
'''耳垂摺痕'''（Earlobe crease），又稱作'''法蘭克徵象'''（Frank's sign），描述[[耳垂]]從[[耳屏]]延伸至[[耳廓]]後緣的對角線摺痕<ref name="Frank">{{cite journal |author=Frank ST |title=Aural sign of coronary-artery disease |journal=N. Engl. J. Med. |volume=289 |issue=6 |pages=327–8 |date=August 1973 |pmid=4718047 |doi= 10.1056/NEJM197308092890622|url=}}</ref><ref name=中醫 />。法蘭克徵象之名以{{tsl|en|Sanders T. Frank|桑德斯·T·法蘭克}}醫師之名命名<ref name="Frank"/>。 |
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目前認為有耳垂摺痕者與較高的[[心血管疾病]]及[[糖尿病]]的發生率相關<ref name="Mall">{{cite journal |last1=Mallinson |first1=Tom |last2=Brooke |first2=David |title=Frank's Sign as a clinical marker of cardiovascular disease |journal=Journal of Paramedic Practice |date=2017 |volume=9 |issue=1 |page=8-10 |doi=10.12968/jpar.2017.9.1.8 |url=https://www.researchgate.net/publication/312104484_Frank's_Sign_as_a_clinical_marker_of_cardiovascular_disease}}</ref><ref>Miot, H.A., Molina de Medeiros, M. etal (2006). [http://www.scielo.br/scielo.php?pid=S0365-05962006000100003&script=sci_arttext&tlng=en Association between [[冠狀動脈疾病|coronary artery disease]] and the diagonal earlobe an preauricular creases in men.] Anais Brasileiros de Dermatologia. vol.81 no.1</ref><ref>{{cite web | url=http://myheart.net/articles/earlobe-crease-and-heart-disease-fact-or-myth/ | title=Earlobe Crease And Heart Disease – Fact Or Myth? | publisher=Abel Healthcare | date=13 August 2014 | accessdate=8 February 2015 | author=Mustafa Ahmed, M.D.}}</ref>。有些研究顯示耳垂摺痕可以作為心血管疾病的一個指標，但與嚴重度無關<ref name="pmid3827155">{{cite journal |vauthors=Lesbre JP, Castier B, Tribouilloy C, Labeille B, Isorni C |title=[Frank's sign and coronary disease] |language=fr |journal=Ann Cardiol Angeiol (Paris) |volume=36 |issue=1 |pages=37–41 |date=January 1987 |pmid=3827155 |doi= |url=}}</ref>。但也有研究指出耳垂摺痕與糖尿病和冠心病並沒有關連性<ref name="pmid11108067">{{cite journal |vauthors=Davis TM, Balme M, Jackson D, Stuccio G, Bruce DG |title=The diagonal ear lobe crease (Frank's sign) is not associated with coronary artery disease or retinopathy in type 2 diabetes: the Fremantle Diabetes Study |journal=Aust N Z J Med |volume=30 |issue=5 |pages=573–7 |date=October 2000 |pmid=11108067 |doi= 10.1111/j.1445-5994.2000.tb00858.x|url=}}</ref> <ref>{{cite news |title=謠言終結站》耳朵有摺痕恐心肌梗塞？國健署解釋曝光 |url=https://news.ltn.com.tw/news/life/breakingnews/2855768 |work=自由時報 |date=2019-07-17 |language=zh-tw}}</ref>。有些研究則著重研究雙側耳垂摺痕<ref name="pmid15539887">{{cite journal |vauthors=Evrengül H, Dursunoğlu D, Kaftan A, etal |title=Bilateral diagonal earlobe crease and coronary artery disease: a significant association |journal=Dermatology |volume=209 |issue=4 |pages=271–5 |year=2004 |pmid=15539887 |doi=10.1159/000080847 |url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=DRM2004209004271 |access-date=2019-08-02 |archive-date=2012-03-06 |archive-url=https://web.archive.org/web/20120306024759/http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=DRM2004209004271 |dead-url=no }}</ref>。 |
目前認為有耳垂摺痕者與較高的[[心血管疾病]]及[[糖尿病]]的發生率相關<ref name="Mall">{{cite journal |last1=Mallinson |first1=Tom |last2=Brooke |first2=David |title=Frank's Sign as a clinical marker of cardiovascular disease |journal=Journal of Paramedic Practice |date=2017 |volume=9 |issue=1 |page=8-10 |doi=10.12968/jpar.2017.9.1.8 |url=https://www.researchgate.net/publication/312104484_Frank's_Sign_as_a_clinical_marker_of_cardiovascular_disease |access-date=2022-02-08 |archive-date=2021-09-03 |archive-url=https://web.archive.org/web/20210903150451/https://www.researchgate.net/publication/312104484_Frank%27s_Sign_as_a_clinical_marker_of_cardiovascular_disease |dead-url=no }}</ref><ref>Miot, H.A., Molina de Medeiros, M. etal (2006). [http://www.scielo.br/scielo.php?pid=S0365-05962006000100003&script=sci_arttext&tlng=en Association between [[冠狀動脈疾病|coronary artery disease]] and the diagonal earlobe an preauricular creases in men.] {{Wayback|url=http://www.scielo.br/scielo.php?pid=S0365-05962006000100003&script=sci_arttext&tlng=en |date=20171215174543 }} Anais Brasileiros de Dermatologia. vol.81 no.1</ref><ref>{{cite web | url=http://myheart.net/articles/earlobe-crease-and-heart-disease-fact-or-myth/ | title=Earlobe Crease And Heart Disease – Fact Or Myth? | publisher=Abel Healthcare | date=13 August 2014 | accessdate=8 February 2015 | author=Mustafa Ahmed, M.D. | archive-date=2020-12-03 | archive-url=https://web.archive.org/web/20201203173450/https://myheart.net/articles/earlobe-crease-and-heart-disease-fact-or-myth/ | dead-url=no }}</ref>。有些研究顯示耳垂摺痕可以作為心血管疾病的一個指標，但與嚴重度無關<ref name="pmid3827155">{{cite journal |vauthors=Lesbre JP, Castier B, Tribouilloy C, Labeille B, Isorni C |title=[Frank's sign and coronary disease] |language=fr |journal=Ann Cardiol Angeiol (Paris) |volume=36 |issue=1 |pages=37–41 |date=January 1987 |pmid=3827155 |doi= |url=}}</ref>。但也有研究指出耳垂摺痕與糖尿病和冠心病並沒有關連性<ref name="pmid11108067">{{cite journal |vauthors=Davis TM, Balme M, Jackson D, Stuccio G, Bruce DG |title=The diagonal ear lobe crease (Frank's sign) is not associated with coronary artery disease or retinopathy in type 2 diabetes: the Fremantle Diabetes Study |journal=Aust N Z J Med |volume=30 |issue=5 |pages=573–7 |date=October 2000 |pmid=11108067 |doi= 10.1111/j.1445-5994.2000.tb00858.x|url=}}</ref> <ref>{{cite news |title=謠言終結站》耳朵有摺痕恐心肌梗塞？國健署解釋曝光 |url=https://news.ltn.com.tw/news/life/breakingnews/2855768 |work=自由時報 |date=2019-07-17 |language=zh-tw |accessdate=2020-08-07 |archive-date=2019-07-18 |archive-url=https://web.archive.org/web/20190718152038/https://news.ltn.com.tw/news/life/breakingnews/2855768 |dead-url=no }}</ref>。有些研究則著重研究雙側耳垂摺痕<ref name="pmid15539887">{{cite journal |vauthors=Evrengül H, Dursunoğlu D, Kaftan A, etal |title=Bilateral diagonal earlobe crease and coronary artery disease: a significant association |journal=Dermatology |volume=209 |issue=4 |pages=271–5 |year=2004 |pmid=15539887 |doi=10.1159/000080847 |url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=DRM2004209004271 |access-date=2019-08-02 |archive-date=2012-03-06 |archive-url=https://web.archive.org/web/20120306024759/http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=DRM2004209004271 |dead-url=no }}</ref>。 |
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一項有關耳垂摺痕形成的假說認為可能是{{tsl|en|premature aging|提早老化}}，造成[[皮下纖維]]及[[血管纖維]]的流失<ref name=中醫>{{cite news |author1=陳凱力 |title=驚！耳垂折痕與心血管疾病有關？ 醫生：這個年紀更要小心 |url=https://health.ettoday.net/news/1425822 |accessdate=2020-08-07 |work=ETtoday新聞雲 |date=2019-04-19 |language=zh-tw}}</ref><ref>{{cite journal | url=http://www.nejm.org/doi/full/10.1056/NEJMicm1213868 | title=Frank's Sign | author=George Griffing, M.D. | journal=The New England Journal of Medicine |date=March 2014 |
一項有關耳垂摺痕形成的假說認為可能是{{tsl|en|premature aging|提早老化}}，造成[[皮下纖維]]及[[血管纖維]]的流失<ref name=中醫>{{cite news |author1=陳凱力 |title=驚！耳垂折痕與心血管疾病有關？ 醫生：這個年紀更要小心 |url=https://health.ettoday.net/news/1425822 |accessdate=2020-08-07 |work=ETtoday新聞雲 |date=2019-04-19 |language=zh-tw}}</ref><ref>{{cite journal | url=http://www.nejm.org/doi/full/10.1056/NEJMicm1213868 | title=Frank's Sign | author=George Griffing, M.D. | journal=The New England Journal of Medicine | date=March 2014 | volume=370 | issue=15 | doi=10.1056/NEJMicm1213868 | access-date=2019-08-02 | archive-date=2019-07-21 | archive-url=https://web.archive.org/web/20190721083415/https://www.nejm.org/doi/full/10.1056/NEJMicm1213868 | dead-url=no }}</ref>。 |
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==參考文獻== |
==參考文獻== |
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2022年2月8日 (二) 18:58的最新版本
耳垂摺痕（Earlobe crease），又稱作法蘭克徵象（Frank's sign），描述耳垂從耳屏延伸至耳廓後緣的對角線摺痕[1][2]。法蘭克徵象之名以桑德斯·T·法蘭克醫師之名命名[1]。
目前認為有耳垂摺痕者與較高的心血管疾病及糖尿病的發生率相關[3][4][5]。有些研究顯示耳垂摺痕可以作為心血管疾病的一個指標，但與嚴重度無關[6]。但也有研究指出耳垂摺痕與糖尿病和冠心病並沒有關連性[7] [8]。有些研究則著重研究雙側耳垂摺痕[9]。
一項有關耳垂摺痕形成的假說認為可能是提早老化，造成皮下纖維及血管纖維的流失[2][10]。
參考文獻[编辑]
- ^ 1.0 1.1 Frank ST. Aural sign of coronary-artery disease. N. Engl. J. Med. August 1973, 289 (6): 327–8. PMID 4718047. doi:10.1056/NEJM197308092890622.
- ^ 2.0 2.1 陳凱力. 驚！耳垂折痕與心血管疾病有關？ 醫生：這個年紀更要小心. ETtoday新聞雲. 2019-04-19 [2020-08-07] （中文（臺灣））.
- ^ Mallinson, Tom; Brooke, David. Frank's Sign as a clinical marker of cardiovascular disease. Journal of Paramedic Practice. 2017, 9 (1): 8-10 [2022-02-08]. doi:10.12968/jpar.2017.9.1.8. （原始内容存档于2021-09-03）.
- ^ Miot, H.A., Molina de Medeiros, M. etal (2006). Association between coronary artery disease and the diagonal earlobe an preauricular creases in men. （页面存档备份，存于互联网档案馆） Anais Brasileiros de Dermatologia. vol.81 no.1
- ^ Mustafa Ahmed, M.D. Earlobe Crease And Heart Disease – Fact Or Myth?. Abel Healthcare. 13 August 2014 [8 February 2015]. （原始内容存档于2020-12-03）.
- ^ Lesbre JP, Castier B, Tribouilloy C, Labeille B, Isorni C. [Frank's sign and coronary disease]. Ann Cardiol Angeiol (Paris). January 1987, 36 (1): 37–41. PMID 3827155 （法语）.
- ^ Davis TM, Balme M, Jackson D, Stuccio G, Bruce DG. The diagonal ear lobe crease (Frank's sign) is not associated with coronary artery disease or retinopathy in type 2 diabetes: the Fremantle Diabetes Study. Aust N Z J Med. October 2000, 30 (5): 573–7. PMID 11108067. doi:10.1111/j.1445-5994.2000.tb00858.x.
- ^ 謠言終結站》耳朵有摺痕恐心肌梗塞？國健署解釋曝光. 自由時報. 2019-07-17 [2020-08-07]. （原始内容存档于2019-07-18） （中文（臺灣））.
- ^ Evrengül H, Dursunoğlu D, Kaftan A, et al. Bilateral diagonal earlobe crease and coronary artery disease: a significant association. Dermatology. 2004, 209 (4): 271–5 [2019-08-02]. PMID 15539887. doi:10.1159/000080847. （原始内容存档于2012-03-06）.
- ^ George Griffing, M.D. Frank's Sign. The New England Journal of Medicine. March 2014, 370 (15) [2019-08-02]. doi:10.1056/NEJMicm1213868. （原始内容存档于2019-07-21）.