跳转到内容

硫酸-4-乙基苯酯：修订间差异

编辑链接
维基百科，自由的百科全书
以互动方式浏览历史
下一版本→
删除的内容 添加的内容
可视化wikitext
←建立内容为“{{chembox | ImageFile = 4-Ethylphenylsulfate_structure.png | OtherNames = ''O''-(4-乙基苯基)硫酸 | Section1 = {{Chembox Identifiers | IUPAC_name = (4-ethylphenyl) hydrogen sulfate | CAS_number = 85734-98-1 | CAS_number_Ref = {{cascite|correct|CAS}} | ChEMBL = | ChemSpiderID = | PubChem = 20822574 | UNII = | smiles = CCC1=CC=C(C=C1)OS(=O)(=O)O | StdInChI = 1S/C8H10O4S/c1-2-7-3-5-8(6-4-7)12-13(9,10)11/h3-6H,2H2,1…”的新页面
标签：加入不可见字符
 
无编辑摘要
标签：加入不可见字符
第18行： 第18行：
}}
}}
}}
}}
'''硫酸-4-乙基苯酯'''是一种单硫酸酯，化学式为C<sub>8</sub>H<sub>10</sub>O<sub>4</sub>S。它可由[[4-乙基苯酚]]和[[三甲胺三氧化硫]]或[[氯磺酸]]反应制得。<ref>{{cite doi|10.1016/j.bmc.2019.01.031}}</ref><ref><ref>Grimes, A. J. Synthesis of S35-​labeled arylsulfates by intact animals and by tissue preparations, with particular reference to L-​tyrosine O-​sulfate. ''Biochemical Journal'', 1959. 73: 732-739. {{issn|0264-6021}}.</ref>
'''硫酸-4-乙基苯酯'''是一种单硫酸酯，化学式为C<sub>8</sub>H<sub>10</sub>O<sub>4</sub>S。它可由[[4-乙基苯酚]]和[[三甲胺三氧化硫]]或[[氯磺酸]]反应制得。<ref>{{cite doi|10.1016/j.bmc.2019.01.031}}</ref><ref>Grimes, A. J. Synthesis of S35-​labeled arylsulfates by intact animals and by tissue preparations, with particular reference to L-​tyrosine O-​sulfate. ''Biochemical Journal'', 1959. 73: 732-739. {{issn|0264-6021}}.</ref>

它是肠道细菌产生的代谢物，大量存在时有毒。这种代谢物水平升高与一些疾病有关，包括[[慢性肾病]]和[[自闭症]]。<ref>{{cite journal | vauthors = Itoh Y, Ezawa A, Kikuchi K, Tsuruta Y, Niwa T | title = Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS | journal = Mass Spectrometry | volume = 2 | issue = Spec Iss | pages = S0017 | pmid = 24349936 | doi = 10.5702/massspectrometry.S0017 }}</ref><ref>{{cite journal | vauthors = Ilievski V, Kinchen JM, Prabhu R, Rim F, Leoni L, Unterman TG, Watanabe K | title = Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses | journal = Journal of Oral Biology | volume = 3 | issue = 1 | pmid = 27390783 | doi = 10.13188/2377-987X.1000020 }}</ref><ref>{{cite journal | vauthors = Virdee MS, Saini N, Kay CD, Neilson AP, Kwan ST, Helfrich KK, Mooney SM, Smith SM | display-authors = 6 | title = An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder | journal = Scientific Reports | volume = 11 | issue = 1 | pages = 248 | date = January 2021 | pmid = 33420159 | doi = 10.1038/s41598-020-80093-8 }}</ref><ref>{{cite journal | vauthors = Zheng Y, Bek MK, Prince NZ, Peralta Marzal LN, Garssen J, Perez Pardo P, Kraneveld AD | title = The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review | journal = Frontiers in Neuroscience | volume = 15 | pages = 738220 | pmid = 34744609 | doi = 10.3389/fnins.2021.738220 }}</ref><ref>{{cite journal | vauthors = Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wu WL, Rabut C, Ladinsky MS, Hwang SJ, Guo Y, Zhu Q, Griffiths JA, Knight R, Bjorkman PJ, Shapiro MG, Geschwind DH, Holschneider DP, Fischbach MA, Mazmanian SK | display-authors = 6 | title = A gut-derived metabolite alters brain activity and anxiety behaviour in mice | journal = Nature | volume = 602 | issue = 7898 | pages = 647–653 | date = February 2022 | pmid = 35165440 | doi = 10.1038/s41586-022-04396-8 }}</ref>


==参考文献==
==参考文献==
{{reflist}}
{{reflist|2}}


[[Category:硫酸酯]]
[[Category:硫酸酯]]

2022年3月5日 (六) 09:23的版本

硫酸-4-乙基苯酯
别名 O-(4-乙基苯基)硫酸
识别
CAS号 85734-98-1  checkY
PubChem 20822574
性质
化学式 C8H10O4S
摩尔质量 202.23 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

硫酸-4-乙基苯酯是一种单硫酸酯，化学式为C8H10O4S。它可由4-乙基苯酚和三甲胺三氧化硫或氯磺酸反应制得。[1][2]

它是肠道细菌产生的代谢物，大量存在时有毒。这种代谢物水平升高与一些疾病有关，包括慢性肾病和自闭症。[3][4][5][6][7]

参考文献

  1. ^ doi:10.1016/j.bmc.2019.01.031
    {{cite doi}}已停用，请参见{{cite journal}}。
  2. ^ Grimes, A. J. Synthesis of S35-​labeled arylsulfates by intact animals and by tissue preparations, with particular reference to L-​tyrosine O-​sulfate. Biochemical Journal, 1959. 73: 732-739. ISSN 0264-6021.
  3. ^ Itoh Y, Ezawa A, Kikuchi K, Tsuruta Y, Niwa T. Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS. Mass Spectrometry: S0017. PMID 24349936. doi:10.5702/massspectrometry.S0017. 
  4. ^ Ilievski V, Kinchen JM, Prabhu R, Rim F, Leoni L, Unterman TG, Watanabe K. Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses. Journal of Oral Biology. PMID 27390783. doi:10.13188/2377-987X.1000020. 
  5. ^ Virdee MS, Saini N, Kay CD, Neilson AP, Kwan ST, Helfrich KK, et al. An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder. Scientific Reports. January 2021, 11 (1): 248. PMID 33420159. doi:10.1038/s41598-020-80093-8. 
  6. ^ Zheng Y, Bek MK, Prince NZ, Peralta Marzal LN, Garssen J, Perez Pardo P, Kraneveld AD. The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience: 738220. PMID 34744609. doi:10.3389/fnins.2021.738220. 
  7. ^ Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, et al. A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature. February 2022, 602 (7898): 647–653. PMID 35165440. doi:10.1038/s41586-022-04396-8. 
检索自“https://zh.wikipedia.org/w/index.php?title=硫酸-4-乙基苯酯&oldid=70467067”