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JWH大麻素列表：修订间差异

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←建立内容为“克莱姆森大学的约翰·威廉·霍夫曼（'''J'''ohn '''W'''illiam '''H'''uffman）研究小组合成了450多种大麻素。<ref>{{cite journal |vauthors=Manera C, Tuccinardi T, Martinelli A |year=2008 |title=Indoles and related compounds as cannabinoid ligands |journal=Mini Rev Med Chem |volume=8 |issue=4 |pages=370–87 |doi=10.2174/138955708783955935 |pmid=18473928}}</ref><ref>{{cite journal |vauthors=Wiley JL, Marusich JA, Huffm…”的新页面
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2023年6月5日 (一) 09:31的版本

克莱姆森大学的约翰·威廉·霍夫曼（John William Huffman）研究小组合成了450多种大麻素。[1][2][3][4]其中一些是：

大麻素及其Ki值[a]
名称 C类别 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构
JWH-004 萘甲酰基吲哚 48 ± 13 4 ± 1.5 CB2 (12x)
JWH-007[5] 萘甲酰基吲哚 9.5 ± 4.5 2.9 ± 2.6 CB2 (3.3x)
JWH-009 萘甲酰基吲哚 >10000 141 ± 14 CB2 (>70x)
JWH-011 萘甲酰基吲哚
JWH-015[5] 萘甲酰基吲哚 164 ± 22 13.8 ± 4.6 CB2 (12x)
JWH-016 萘甲酰基吲哚 22 ± 1.5 4.3 ± 1.6 CB2 (5.1x)
JWH-018[5] 萘甲酰基吲哚 9 ± 5 2.9 ± 2.6 CB2 (3.1x)
JWH-019 萘甲酰基吲哚 9.8 ± 2 5.55 ± 2 CB2 (1.77x)
JWH-020 萘甲酰基吲哚 128 ± 17 205 ± 20 CB1 (1.6x)
JWH-030 萘甲酰基吡咯 87 ± 3 320 ± 127 CB1 (3.7x)
JWH-031 萘甲酰基吡咯 399 ± 109
JWH-032 萘甲酰基吡咯 >10000 >10000 —
JWH-033 萘甲酰基吡咯 666 ± 77
JWH-036 萘甲酰基吡咯 309 ± 11
JWH-042[6] 萘甲酰基吲哚 >10000 5050 ± 192 CB2
JWH-043[6] 萘甲酰基吲哚 1180 ± 44 964 ± 242 CB2 (1.2x)
JWH-044 萘甲酰基吡咯 >10000 >10000 —
JWH-045 萘甲酰基吡咯 >10000 >10000 —
JWH-046[6] 萘甲酰基吲哚 343 ± 38 16.3 ± 4.9 CB2 (21x)
JWH-047[6] 萘甲酰基吲哚 59 ± 3 3.47 ± 1.80 CB2 (17x)
JWH-048[6] 萘甲酰基吲哚 10.7 ± 1.0 0.49 ± 0.13 CB2 (22x)
JWH-049[6] 萘甲酰基吲哚 55.1 ± 17.0 32.3 ± 2.4 CB2 (1.7x)
JWH-050[6] 萘甲酰基吲哚 342 ± 6 526 ± 133 CB1 (1.5x)
JWH-051 二苯并吡喃 1.20 0.03 CB2 (40x)
JWH-056[7] 二苯并吡喃 >10000 32 ± 9 CB2
JWH-057[8] 二苯并吡喃 23 ± 7 2.9 ± 1.6 CB2 (8x)
JWH-065[7] 二苯并吡喃 399 ± 76 10 ± 2 CB2 (40x)
JWH-070[6] 萘甲酰基吲哚 >10000 >10000
JWH-071[6] 萘甲酰基吲哚 1340 ± 123 2940 ± 852 CB1 (2.2x)
JWH-072 萘甲酰基吲哚 1050 ± 5.5 170 ± 54 CB2 (6x)
JWH-073 萘甲酰基吲哚 8.9 ± 1.8 27 ± 12 CB1 (3x)
JWH-076[5] 萘甲酰基吲哚 214 ± 11 106 ± 46 CB2 (2x)
JWH-077[6] 萘甲酰基吲哚 >10000 >10000
JWH-078[6] 萘甲酰基吲哚 817 ± 60 633 ± 116 CB2 (1.3x)
JWH-079[6] 萘甲酰基吲哚 63.0 ± 3.0 32.0 ± 6.0 CB2 (2x)
JWH-080[6] 萘甲酰基吲哚 8.9 ± 1.8 2.21 ± 1.30 CB2 (4x)
JWH-081[6] 萘甲酰基吲哚 1.2 ± 0.03 12.4 ± 2.2 CB1 (10x)
JWH-082[6] 萘甲酰基吲哚 5.3 ± 0.8 6.40 ± 0.94 CB1 (1.2x)
JWH-083[6] 萘甲酰基吲哚 106 ± 12 102 ± 50 —
JWH-091[9] (Δ8-THCP) 二苯并吡喃 22.0 ± 3.9
JWH-093[6] 萘甲酰基吲哚 40.7 ± 2.8 59.1 ± 10.5 CB1 (1.45x)
JWH-094[6] 萘甲酰基吲哚 476 ± 67 97.3 ± 2.7 CB2 (4.9x)
JWH-095[6] 萘甲酰基吲哚 140 ± 4.3 312 ± 83 CB1 (2.2x)
JWH-096[6] 萘甲酰基吲哚 33.7 ± 2.9 13.3 ± 5.6 CB2 (2.5x)
JWH-097[6] 萘甲酰基吲哚 455 ± 28 121 ± 15 CB2 (3.8x)
JWH-098[6] 萘甲酰基吲哚 4.5 ± 0.1 1.9 ± 0.3 CB2 (2.4x)
JWH-099[6] 萘甲酰基吲哚 35.3 ± 9.0 17.8 ± 2.9 CB2 (2x)
JWH-100[6] 萘甲酰基吲哚 381 ± 102 155 ± 74 CB2 (2.5x)
JWH-102[7] 二苯并吡喃 7.9 ± 0.9 5.2 ± 2.0 CB2 (1.5x)
JWH-103[7] 二苯并吡喃 28 ± 3 23 ± 7 CB2 (1.2x)
JWH-116[10] 萘甲酰基吲哚 52 ± 5
JWH-120[5] 萘甲酰基吲哚 1054 ± 31 6.1 ± 0.7 CB2 (173x)
JWH-122[10] 萘甲酰基吲哚 0.69 ± 0.05 1.2 ± 1.2 —
JWH-124 (Δ8-Parahexyl) 二苯并吡喃 41.0 ± 3.8
JWH-130 (Δ8-THCB) 二苯并吡喃 65.0 ± 13
JWH-133[7] 二苯并吡喃 677 ± 132 3.4 ± 1.0 CB2 (200x)
JWH-138[11] 二苯并吡喃 8.5 ± 1.4
JWH-139[12] 二苯并吡喃 2290 ± 505 14 ± 10 CB2 (164x)
JWH-142[7] 二苯并吡喃 529 ± 49 35 ± 14 CB2 (15x)
JWH-143[7] 二苯并吡喃 924 ± 104 65 ± 8 CB2 (14x)
JWH-145[13] 萘甲酰基吡咯 14 ± 2 6.4 ± 0.4 CB2 (2.2x)
JWH-146[13] 萘甲酰基吡咯 21 ± 2 62 ± 5 CB2 (3.0x)
JWH-147[13] 萘甲酰基吡咯 11 ± 1 7.1 ± 0.2 CB2 (1.5x)
JWH-148[5] 萘甲酰基吲哚 123 ± 8 14.0 ± 1.0 CB2 (8x)
JWH-149[5] 萘甲酰基吲哚 5.0 ± 2.1 0.73 ± 0.03 CB2 (6.8x)
JWH-150[13] 萘甲酰基吡咯 60 ± 1 15 ± 2 CB2 (4x)
JWH-151[5] 萘甲酰基吲哚 >10000 30 ± 1.1 CB2 (>333x)
JWH-153[5] 萘甲酰基吲哚 250 ± 24 11 ± 0.5 CB2 (23x)
JWH-156[13] 萘甲酰基吡咯 404 ± 18 104 ± 18 CB2 (4x)
JWH-159[5] 萘甲酰基吲哚 45 ± 1 10.4 ± 1.4 CB2 (4.3x)
JWH-160[5] 萘甲酰基吲哚 1568 ± 201 441 ± 110 CB2 (3.6x)
JWH-161 二苯并吡喃合体 19.0
JWH-163[5] 萘甲酰基吲哚 2358 ± 215 138 ± 12 CB2 (17x)
JWH-164[5] 萘甲酰基吲哚 6.6 ± 0.7 6.9 ± 0.2 —
JWH-165[5] 萘甲酰基吲哚 204 ± 26 71 ± 8 CB2 (2.9x)
JWH-166[5] 萘甲酰基吲哚 44 ± 10 1.9 ± 0.08 CB2 (23x)
JWH-167 苯乙酰吲哚 90 ± 17 159 ± 14 CB1 (1.77x)
JWH-171 碳氢 51
JWH-175[10] 萘甲基吲哚 22 ± 2
JWH-176[10] 碳氢 26 ± 4
JWH-180[5] 萘甲酰基吲哚 26 ± 2 9.6 ± 2.0 CB2 (2.7x)
JWH-181[5] 萘甲酰基吲哚 1.3 ± 0.1 0.62 ± 0.04 CB2 (2.1x)
JWH-182[5] 萘甲酰基吲哚 0.65 ± 0.03 1.1 ± 0.1 CB1 (1.7x)
JWH-184[10] 萘甲基吲哚 23 ± 6
JWH-185[10] 萘甲基吲哚 17 ± 3
JWH-186[14] 二苯并吡喃 187 ± 23 5.6 ± 1.7 CB2 (33x)
JWH-187[14] 二苯并吡喃 84 ± 16 3.4 ± 0.5 CB2 (25x)
JWH-188[14] 二苯并吡喃 270 ± 58 18 ± 2 CB2 (15x)
JWH-189[5] 萘甲酰基吲哚 52 ± 2 12 ± 0.8 CB2 (4.3x)
JWH-190[14] 二苯并吡喃 8.8 ± 1.4 1.6 ± 0.03 CB2 (5.5x)
JWH-191[14] 二苯并吡喃 1.8 ± 0.3 0.52 ± 0.03 CB2 (3.5x)
JWH-192[10] 萘甲基吲哚 41 ± 13
JWH-193[10] 萘甲酰基吲哚 6 ± 1
JWH-194[10] 萘甲基吲哚 127 ± 19
JWH-195[10] 萘甲基吲哚 113 ± 28
JWH-196[10] 萘甲基吲哚 151 ± 18
JWH-197[10] 萘甲基吲哚 323 ± 98
JWH-198[10] 萘甲酰基吲哚 10 ± 2
JWH-199[10] 萘甲基吲哚 20 ± 2
JWH-200[10] 萘甲酰基吲哚 42 ± 5
JWH-201[15] 苯乙酰吲哚 1064 ± 21 444 ± 14 CB2 (2.4x)
JWH-202[15] 苯乙酰吲哚 1678 ± 63 645 ± 6 CB2 (2.6x)
JWH-203[15] 苯乙酰吲哚 8.0 ± 0.9 7.0 ± 1.3 —
JWH-204[15] 苯乙酰吲哚 13 ± 1 25 ± 1 CB1 (1.9x)
JWH-205[15] 苯乙酰吲哚 124 ± 23 180 ± 9 CB1 (1.45x)
JWH-206[15] 苯乙酰吲哚 389 ± 25 498 ± 37 CB1 (1.28x)
JWH-207[15] 苯乙酰吲哚 1598 ± 134 3723 ± 10 CB1 (2.33x)
JWH-208[15] 苯乙酰吲哚 179 ± 7 570 ± 127 CB1 (3.18x)
JWH-209[15] 苯乙酰吲哚 746 ± 49 1353 ± 270 CB1 (1.81x)
JWH-210[5] 萘甲酰基吲哚 0.46 ± 0.03 0.69 ± 0.01 CB1 (1.5x)
JWH-211[5] 萘甲酰基吲哚 70 ± 0.8 12 ± 0.8 CB2 (5.8x)
JWH-212[5] 萘甲酰基吲哚 33 ± 0.9 10 ± 1.2 CB2 (3.3x)
JWH-213[5] 萘甲酰基吲哚 1.5 ± 0.2 0.42 ± 0.05 CB2 (3.6x)
JWH-215[14] 二苯并吡喃 1008 ± 117 85 ± 21 CB2 (12x)
JWH-216[14] 二苯并吡喃 1856 ± 148 333 ± 104 CB2 (5.6x)
JWH-217[14] 二苯并吡喃 >10000 1404 ± 66 CB2 (>7x)
JWH-220 碳氢 19
JWH-224[14] 二苯并吡喃 347 ± 34 28 ± 1 CB2 (12.3x)
JWH-225[14] 二苯并吡喃 >10000 325 ± 70 CB2 (>31x)
JWH-226[14] 二苯并吡喃 4001 ± 282 43 ± 3 CB2 (93x)
JWH-227[14] 二苯并吡喃 40 ± 6 4.4 ± 0.3 CB2 (9x)
JWH-229[16] 二苯并吡喃 3134 ± 110 18 ± 2 CB2 (174x)
JWH-230[14] 二苯并吡喃 15 ± 3 1.4 ± 0.12 CB2 (10.7x)
JWH-233[14] 二苯并吡喃 14 ± 3 1.0 ± 0.3 CB2 (14x)
JWH-234[5] 萘甲酰基吲哚 8.4 ± 1.8 3.8 ± 0.6 CB2 (2.2x)
JWH-235[5] 萘甲酰基吲哚 338 ± 34 123 ± 34 CB2 (2.7x)
JWH-236[5] 萘甲酰基吲哚 1351 ± 204 240 ± 63 CB2 (5.6x)
JWH-237[15] 苯乙酰吲哚 38 ± 10 106 ± 2 CB1 (2.8x)
JWH-239[5] 萘甲酰基吲哚 342 ± 20 52 ± 6 CB2 (6.6x)
JWH-240[5] 萘甲酰基吲哚 14 ± 1 7.2 ± 1.3 CB2 (1.9x)
JWH-241[5] 萘甲酰基吲哚 147 ± 20 49 ± 7 CB2 (3.0x)
JWH-242[5] 萘甲酰基吲哚 42 ± 9 6.5 ± 0.3 CB2 (6.5x)
JWH-243[13] 萘甲酰基吡咯 285 ± 40 41 ± 3 CB2 (6.95x)
JWH-244[13] 萘甲酰基吡咯 130 ± 6 18 ± 1 CB2 (7.22x)
JWH-245[13] 萘甲酰基吡咯 276 ± 4 25 ± 2 CB2 (11x)
JWH-246[13] 萘甲酰基吡咯 70 ± 4 16 ± 1 CB2 (4.38x)
JWH-247[14] 二苯并吡喃 427 ± 31 99 ± 4 CB2 (4.3x)
JWH-248[15] 苯乙酰吲哚 1028 ± 39 657 ± 19 CB2 (1.56x)
JWH-249[15] 苯乙酰吲哚 8.4 ± 1.8 20 ± 2 CB1 (2.38x)
JWH-250[15] 苯乙酰吲哚 11 ± 2 33 ± 2 CB1 (3x)
JWH-251[15] 苯乙酰吲哚 29 ± 3 146 ± 36 CB2 (5x)
JWH-252[15] 苯乙酰吲哚 23 ± 3 19 ± 1 CB2 (1.2x)
JWH-253[15] 苯乙酰吲哚 62 ± 10 84 ± 12 CB1 (1.35x)
JWH-254[14] 二苯并吡喃 4724 ± 509 319 ± 16 CB2 (14.8x)
JWH-256[14] 二苯并吡喃 4300 ± 888 97 ± 18 CB2 (44x)
JWH-258[5] 萘甲酰基吲哚 4.6 ± 0.6 10.5 ± 1.3 CB1 (2.3x)
JWH-259[5] 萘甲酰基吲哚 220 ± 29 74 ± 7 CB2 (3.0x)
JWH-260[5] 萘甲酰基吲哚 29 ± 0.4 25 ± 1.9 CB2 (1.2x)
JWH-261[5] 萘甲酰基吲哚 767 ± 105 221 ± 14 CB2 (3.5x)
JWH-262[5] 萘甲酰基吲哚 28 ± 3 5.6 ± 0.7 CB2 (5.0x)
JWH-265[5] 萘甲酰基吲哚 3788 ± 323 80 ± 13 CB2 (47x)
JWH-266[5] 萘甲酰基吲哚 >10000 455 ± 55 CB2 (>22x)
JWH-267[5] 萘甲酰基吲哚 381 ± 16 7.2 ± 0.14 CB2 (53x)
JWH-268[5] 萘甲酰基吲哚 1379 ± 193 40 ± 0.6 CB2 (34x)
JWH-277[14] 二苯并吡喃 3905 ± 91 589 ± 65 CB2 (6.6x)
JWH-278[14] 二苯并吡喃 906 ± 80 69 ± 6 CB2 (13x)
JWH-292[13] 萘甲酰基吡咯 29 ± 1 20 ± 1 CB2 (1.45x)
JWH-293[13] 萘甲酰基吡咯 100 ± 5 41 ± 4 CB2 (2.44x)
JWH-298[14] 二苯并吡喃 812 ± 67 198 ± 23 CB2 (4.1x)
JWH-299[14] 二苯并吡喃 415 ± 50 30 ± 2 CB2 (13.8x)
JWH-300[12] 二苯并吡喃 118 ± 16 5.3 ± 0.1 CB2 (22x)
JWH-301[14] 二苯并吡喃 295 ± 64 48 ± 4 CB2 (6.1x)
JWH-302[15] 苯乙酰吲哚 17 ± 2 89 ± 15 CB1 (5.26x)
JWH-303[15] 苯乙酰吲哚 117 ± 10 138 ± 12 CB1 (1.18x)
JWH-304[15] 苯乙酰吲哚 3363 ± 332 2679 ± 688 CB2 (1.26x)
JWH-305[15] 苯乙酰吲哚 15 ± 1.8 29 ± 5 CB1 (1.93x)
JWH-306[15] 苯乙酰吲哚 25 ± 1 82 ± 11 CB1 (3.28x)
JWH-307[13] 萘甲酰基吡咯 7.7 ± 1.8 3.3 ± 0.2 CB2 (2.33x)
JWH-308[13] 萘甲酰基吡咯 41 ± 1 33 ± 2 CB2 (1.24x)
JWH-309[13] 萘甲酰基吡咯 41 ± 3 49 ± 7 CB1 (1.20x)
JWH-310[14] 二苯并吡喃 1059 ± 51 36 ± 3 CB2 (29x)
JWH-311[15] 苯乙酰吲哚 23 ± 2 39 ± 3 CB1 (1.70x)
JWH-312[15] 苯乙酰吲哚 72 ± 7 91 ± 20 CB1 (1.26x)
JWH-313[15] 苯乙酰吲哚 422 ± 19 365 ± 92 CB2 (1.16x)
JWH-314[15] 苯乙酰吲哚 39 ± 2 76 ± 4 CB1 (1.95x)
JWH-315[15] 苯乙酰吲哚 430 ± 24 182 ± 23 CB2 (3.36x)
JWH-316[15] 苯乙酰吲哚 2862 ± 670 781 ± 105 CB2 (3.66x)
JWH-336[12] 二苯并吡喃 4589 ± 367 153 ± 15 CB2 (30x)
JWH-338[14] 二苯并吡喃 >10000 111 ± 16 CB2 (>90x)
JWH-339[14] 二苯并吡喃 >10000 2317 ± 93 CB2 (>4.3x)
JWH-340[14] 二苯并吡喃 135 ± 6 30 ± 1 CB2 (4.5x)
JWH-341[14] 二苯并吡喃 100 ± 8 10 ± 0.1 CB2 (10x)
JWH-346[13] 萘甲酰基吡咯 67 ± 6 39 ± 2 CB2 (1.72x)
JWH-347[13] 萘甲酰基吡咯 333 ± 17 169 ± 17 CB2 (1.97x)
JWH-348[13] 萘甲酰基吡咯 218 ± 19 53 ± 1 CB2 (4.11x)
JWH-349[14] 二苯并吡喃 376 ± 1 38 ± 4 CB2 (9.9x)
JWH-350[12] 二苯并吡喃 395 ± 50 12 ± 1 CB2 (33x)
JWH-351[14] 二苯并吡喃 >10000 295 ± 3 CB2 (>34x)
JWH-352[14] 二苯并吡喃 >10000 47 ± 2 CB2 (>213x)
JWH-353[14] 二苯并吡喃 1493 ± 10 31 ± 1 CB2 (48x)
JWH-354[14] 二苯并吡喃 1961 ± 21 241 ± 14 CB2 (8.1x)
JWH-355[14] 二苯并吡喃 2162 ± 220 108 ± 17 CB2 (20x)
JWH-356[14] 二苯并吡喃 5837 ± 701 108 ± 17 CB2 (54x)
JWH-357[14] 二苯并吡喃 647 ± 78 185 ± 4 CB2 (3.5x)
JWH-358[14] 二苯并吡喃 1243 ± 266 52 ± 3 CB2 (24x)
JWH-359 二苯并吡喃 2918 ± 450 13.0 ± 0.2 CB2 (220x)
JWH-360[14] 二苯并吡喃 2449 ± 606 160 ± 8 CB2 (15x)
JWH-361[14] 二苯并吡喃 63 ± 3 2.7 ± 0.1 CB2 (23x)
JWH-362[14] 二苯并吡喃 127 ± 8 34 ± 5 CB2 (3.7x)
JWH-363[13] 萘甲酰基吡咯 245 ± 5 71 ± 1 CB2 (3.45x)
JWH-364[13] 萘甲酰基吡咯 34 ± 3 29 ± 1 CB2 (1.17x)
JWH-365[13] 萘甲酰基吡咯 17 ± 1 3.4 ± 0.2 CB2 (5.0x)
JWH-366[13] 萘甲酰基吡咯 191 ± 12 24 ± 1 CB2 (7.96x)
JWH-367[13] 萘甲酰基吡咯 53 ± 2 23 ± 1 CB2 (2.30x)
JWH-368[13] 萘甲酰基吡咯 16 ± 1 9.1 ± 0.7 CB2 (1.76x)
JWH-369[13] 萘甲酰基吡咯 7.9 ± 0.4 5.2 ± 0.3 CB2 (1.52x)
JWH-370[13] 萘甲酰基吡咯 5.6 ± 0.4 4.0 ± 0.5 CB2 (1.40x)
JWH-371[13] 萘甲酰基吡咯 42 ± 1 64 ± 2 CB1 (1.52x)
JWH-372[13] 萘甲酰基吡咯 77 ± 2 8.2 ± 0.2 CB1 (9.39x)
JWH-373[13] 萘甲酰基吡咯 60 ± 3 69 ± 2 CB1 (1.15x)
JWH-387[17] 萘甲酰基吲哚 1.2 ± 0.1 1.1 ± 0.1 —
JWH-398[18] 萘甲酰基吲哚 2.3 ± 0.1 2.8 ± 0.2 CB1 (1.22x)
JWH-416[17] 萘甲酰基吲哚 73 ± 10 3.3 ± 0.1 CB2 (22x)
JWH-417[17] 萘甲酰基吲哚 522 ± 58 13 ± 0.2 CB2 (40x)
JWH-422[17] 萘甲酰基吲哚 501 ± 48 20 ± 0.4 CB2 (25x)
JWH-423[17] 萘甲酰基吲哚 140 ± 10 6.6 ± 0.2 CB2 (21x)
JWH-424[17] 萘甲酰基吲哚 21 ± 3.4 5.4 ± 0.2 CB2 (3.9x)
JWH-425[17] 萘甲酰基吲哚 54 ± 11 10 ± 0.4 CB2 (5.4x)

参见

注释

  1. ^ Ki是化合物对大麻素1型受体（CB1）或大麻素2型受体（CB2）的结合亲和力

参考资料

  1. ^ Manera C, Tuccinardi T, Martinelli A. Indoles and related compounds as cannabinoid ligands. Mini Rev Med Chem. 2008, 8 (4): 370–87. PMID 18473928. doi:10.2174/138955708783955935. 
  2. ^ Wiley JL, Marusich JA, Huffman JW. Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids. Life Sci. 2014, 97 (1): 55–63. PMC 3944940 可免费查阅. PMID 24071522. doi:10.1016/j.lfs.2013.09.011. 
  3. ^ Wiley JL, Marusich JA, Thomas BF. Combination Chemistry: Structure-Activity Relationships of Novel Psychoactive Cannabinoids. Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 2017, 32: 231–248. ISBN 978-3-319-52442-9. PMID 27753007. doi:10.1007/7854_2016_17 可免费查阅. 
  4. ^ Banister SD, Connor M. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins. Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 2018, 252: 165–190. ISBN 978-3-030-10560-0. PMID 29980914. doi:10.1007/164_2018_143. 
  5. ^ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 5.31 5.32 5.33 5.34 5.35 5.36 5.37 5.38 Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorganic & Medicinal Chemistry. January 2005, 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050. 
  6. ^ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug and Alcohol Dependence. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0. 
  7. ^ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR. 3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry. December 1999, 7 (12): 2905–14. PMID 10658595. doi:10.1016/s0968-0896(99)00219-9. 
  8. ^ Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. Journal of Medicinal Chemistry. September 1996, 39 (20): 3875–7. PMID 8831752. doi:10.1021/JM960394Y. 
  9. ^ Bow EW, Rimoldi JM. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspect Medicin Chem. 2016 Jun 28;8:17-39. doi:10.4137/PMC.S32171 PMID 27398024
  10. ^ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 10.13 10.14 Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor. Bioorganic & Medicinal Chemistry. February 2003, 11 (4): 539–49. PMID 12538019. S2CID 29107765. doi:10.1016/S0968-0896(02)00451-0. 
  11. ^ Martin BR, Jefferson R, Winckler R, Wiley JL, Huffman JW, Crocker PJ, Saha B, Razdan RK. Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. J Pharmacol Exp Ther. 1999 Sep;290(3):1065-79. PMID 10454479
  12. ^ 12.0 12.1 12.2 12.3 Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. June 2002, 54 (2): 161–202. PMID 12037135. S2CID 8259002. doi:10.1124/pr.54.2.161. 
  13. ^ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 13.15 13.16 13.17 13.18 13.19 13.20 13.21 13.22 13.23 13.24 13.25 13.26 13.27 Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters. October 2006, 16 (20): 5432–5. PMID 16889960. doi:10.1016/j.bmcl.2006.07.051. 
  14. ^ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 14.11 14.12 14.13 14.14 14.15 14.16 14.17 14.18 14.19 14.20 14.21 14.22 14.23 14.24 14.25 14.26 14.27 14.28 14.29 14.30 14.31 14.32 14.33 14.34 14.35 14.36 14.37 14.38 Marriott KS, Huffman JW. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Current Topics in Medicinal Chemistry. 2008, 8 (3): 187–204. PMID 18289088. doi:10.2174/156802608783498014. 
  15. ^ 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 15.12 15.13 15.14 15.15 15.16 15.17 15.18 15.19 15.20 15.21 15.22 15.23 15.24 15.25 15.26 Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & Medicinal Chemistry Letters. September 2005, 15 (18): 4110–3. PMID 16005223. doi:10.1016/j.bmcl.2005.06.008. 
  16. ^ Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR. 1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry. December 2002, 10 (12): 4119–29. PMID 12413866. doi:10.1016/s0968-0896(02)00331-0. 
  17. ^ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW. Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents. Bioorganic & Medicinal Chemistry. 2012, 20 (6): 2067–2081. PMC 3298571 可免费查阅. PMID 22341572. doi:10.1016/j.bmc.2012.01.038. 
  18. ^ The Cannabinoid Receptors. The Receptors. 2009. ISBN 978-1-58829-712-9. doi:10.1007/978-1-59745-503-9. 
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