3,5-二叔丁基水杨醛

3,5-Di-tert-butylsalicylaldehyde
	IUPAC名; 3,5-Di-tert-butyl-2-hydroxybenzaldehyde
识别
CAS号	37942-07-7
PubChem	688023
ChemSpider	599518
SMILES	O=Cc1cc(cc(c1O)C(C)(C)C)C(C)(C)C;
InChI	InChI=1S/C15H22O2/c1-14(2,3)11-7-10(9-16)13(17)12(8-11)15(4,5)6/h7-9,17H,1-6H3;
性质
化学式	C15H22O2
摩尔质量	234.33 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

3,5-二叔丁基水杨醛（英語：3,5-Di-tert-butylsalicylaldehyde，也称为3,5-二叔丁基-2-羟基苯甲醛，3,5-Di-tert-butyl-2-hydroxybenzaldehyde），分子式C₁₅H₂₂O₂，常温常压下为淡黄色固体，是合成Salen配体的前体^[1]。

它可通过2,4-二叔丁基苯酚的达夫反应制备：^[1]

2,4-二叔丁基苯酚和多聚甲醛在三乙胺和氯化镁的存在下于四氢呋喃中反应，也能得到3,5-二叔丁基水杨醛。^[2]

参考文献

^ ^1.0 ^1.1 Jay F. Larrow and Eric N. Jacobsen (2004). "(R,R)-N,N'-Bis(3,5-Di-tert-Butylsalicylidene)-1,2-Cyclohexanediamino Manganese(III) Chloride, A Highly Enantioselective Epoxidation Catalyst". Org. Synth.; Coll. Vol. 10: 96.
^ Yingying Ren, Qishun Yu, Chengrong Lu, and Bei Zhao. Enantioselective Michael Addition of Malononitrile to Unsaturated Ketones Catalyzed by Rare-Earth Metal Amides RE[N(SiMe3)2]3 with Phenoxy-Functionalized TsDPEN Ligands. J. Org. Chem. 2023, 88, 18, 13205–13213. doi:10.1021/acs.joc.3c01435.

外部链接

[jacobsen-1] 1.0 ^1.1 Jay F. Larrow and Eric N. Jacobsen (2004). "(R,R)-N,N'-Bis(3,5-Di-tert-Butylsalicylidene)-1,2-Cyclohexanediamino Manganese(III) Chloride, A Highly Enantioselective Epoxidation Catalyst". Org. Synth.; Coll. Vol. 10: 96.

[2] Yingying Ren, Qishun Yu, Chengrong Lu, and Bei Zhao. Enantioselective Michael Addition of Malononitrile to Unsaturated Ketones Catalyzed by Rare-Earth Metal Amides RE[N(SiMe3)2]3 with Phenoxy-Functionalized TsDPEN Ligands. J. Org. Chem. 2023, 88, 18, 13205–13213. doi:10.1021/acs.joc.3c01435.

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