鲨烯-藿烯环化酶

Squalene-hopene cyclase
	鲨烯-藿烯环化酶二聚体的晶体结构
命名
系统命名
缩写
识别码
EC編號	or 4/2/1/129.html 5.4.99.17
CAS号	76600-69-6
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IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
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PMC	相关文献
PubMed	相关文献

鲨烯-藿烯环化酶（英語：Squalene-hopene cyclase，缩写SHC，EC 5.4.99.17）或称作藿烷-22-醇水裂解酶（hopan-22-ol hydro-lyase，EC 4.2.1.129）属于原核生物中生成五环三萜的环化/变位酶家族，能催化下列两种反应，生成藿烯或藿烷-22-醇，两种产物的比例为5比1^[1]^[2]^[3]^[4]^[5]：

鲨烯

\rightleftharpoons

22(29)-藿烯

鲨烯 + H₂O

\rightleftharpoons

藿烷-22-醇

参考文献

^ Hoshino T, Sato T. Squalene-hopene cyclase: catalytic mechanism and substrate recognition. Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.
^ Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.
^ Sato T, Kouda M, Hoshino T. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.
^ Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.
^ Pearson A, Budin M, Brocks JJ. Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571 . PMID 14660793. doi:10.1073/pnas.2536559100.

外部链接

醫學主題詞表（MeSH）：Squalene-hopene+cyclase

[1] Hoshino T, Sato T. Squalene-hopene cyclase: catalytic mechanism and substrate recognition. Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.

[2] Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.

[3] Sato T, Kouda M, Hoshino T. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.

[Reinert,_D.J.,_Balliano,_G._and_Schulz,_G.E._2004_121–126-4] Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.

[Pearson,_A.,_Budin,_M.,_and_Brocks,_J._2003_15352–15357-5] Pearson A, Budin M, Brocks JJ. Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571 . PMID 14660793. doi:10.1073/pnas.2536559100.

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查论编異構酶：变位酶类（EC 5.4）
5.4.1：酰基变位酶	溶血卵磷脂酰基变位酶
5.4.2：磷酸变位酶	磷酸甘油酸变位酶二磷酸甘油酸变位酶磷酸葡糖变位酶磷酸甘露糖变位酶 PMM1 PMM2 磷酸烯醇式丙酮酸变位酶
5.4.99：其他基团	甲基丙二酸单酰辅酶A变位酶羊毛固醇合酶
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英语：Template:Ligases CO CS and CN）/4/5-6