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研究中心 京都大学

KEGG英语Kyoto Encyclopedia of Genes and Genomes京都基因與基因组百科全書日语京都遺伝子ゲノム百科事典)是一套日本於1995年制定的人類基因組計劃,此為關於基因组酶促途径以及生物化学物质在线数据库。其途径数据库PATHWAY之中记录的是细胞之中的分子相互作用网络以及具体生物所特有的变化形式。 但是它有一個缺點『無法由網頁介面作進一步的計算,例如建立複雜的調控網,或是找出反應之間可能的交互作用』。


KEGG数据库项目是金久实在1995年首次提出的,金久实是京都大学化学研究所的教授, under the then ongoing Japanese Human Genome Program.[1][2] Foreseeing the need for a computerized resource that can be used for biological interpretation of genome sequence data, he started developing the KEGG PATHWAY database. It is a collection of manually drawn KEGG pathway maps representing experimental knowledge on metabolism and various other functions of the cell and the organism. Each pathway map contains a network of molecular interactions and reactions and is designed to link genes in the genome to gene products (mostly proteins) in the pathway. This has enabled the analysis called KEGG pathway mapping, whereby the gene content in the genome is compared with the KEGG PATHWAY database to examine which pathways and associated functions are likely to be encoded in the genome.

According to the developers, KEGG is a "computer representation" of the biological system.[3] It integrates building blocks and wiring diagrams of the system — more specifically, genetic building blocks of genes and proteins, chemical building blocks of small molecules and reactions, and wiring diagrams of molecular interaction and reaction networks. This concept is realized in the following databases of KEGG, which are categorized into systems, genomic, chemical, and health information.[4]

  • 系统信息
    • PATHWAY — pathway maps for cellular and organismal functions
    • MODULE — modules or functional units of genes
    • BRITE — hierarchical classifications of biological entities
  • 基因组信息
    • GENOME — complete genomes
    • GENES — genes and proteins in the complete genomes
    • ORTHOLOGY — ortholog groups of genes in the complete genomes
  • 化学信息
  • 健康信息