ABT-724

**ABT-724**
识别信息
	IUPAC命名法 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole; ;
CAS号	70006-24-5
PubChem CID	5025739;
ChemSpider	4204515 ;
UNII	4WV2575JWT;
ChEMBL	ChEMBL440687 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID001025592 ;
化学信息
化学式	C17H19N5
摩尔质量	293.37 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES n2c1ccccc1[nH]c2CN(CC4)CCN4c3ncccc3;
	InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20) ; Key:FRPJGTNLZNXQEX-UHFFFAOYSA-N ;

ABT-724是一种含氮有机化合物，分子式C₁₇H₁₉N₅，是一种多巴胺受体D₄的选择性激动剂^[1]，作为治疗勃起功能障碍的潜在药物而开发^[2]。

参考文献[编辑]

^ Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proceedings of the National Academy of Sciences of the United States of America. April 2004, 101 (17): 6758–6763. Bibcode:2004PNAS..101.6758B. PMC 404118 . PMID 15087502. doi:10.1073/pnas.0308292101 .
^ Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, et al. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. Journal of Medicinal Chemistry. July 2004, 47 (15): 3853–3864. PMID 15239663. doi:10.1021/jm030505a.