Chapter 48, "SYNTHESIS OF THYROID HORMONES" in: Walter F., PhD. Boron (2003年) 《 Medical Physiology: A Cellular And Molecular Approaoch》、Elsevier/Saunders、pp. 1,300 ISBN: 1-4160-2328-3.
Iodine (I0) is very reactive and iodinates the thyroglobulin at tyrosyl residues in its protein chain (in total containing approximately 120 tyrosyl residues).
In conjugation, adjacent tyrosyl residues are paired together.
The entire complex re-enters the follicular cell by endocytosis.