皮质抑素A

皮质抑素A
	IUPAC名; (1R,2R,3S,5R,8β,17β)-3-(Dimethylamino)-17-(isoquinolin-7-yl)-5,8-epoxy-9,19-cyclo-9,10-secoandrosta-9(11),10-diene-1,2-diol
别名	Cortistatine A
识别
CAS号	882976-95-6
PubChem	11561907
ChemSpider	9736681
SMILES	C[C@]12CC=C3C=C4[C@H]([C@@H]([C@H](C[C@]45CC[C@@]3([C@@H]1CC[C@@H]2c6ccc7ccncc7c6)O5)N(C)C)O)O;
InChI	1/C30H36N2O3/c1-28-10-8-21-15-23-26(33)27(34)24(32(2)3)16-29(23)11-12-30(21,35-29)25(28)7-6-22(28)19-5-4-18-9-13-31-17-20(18)14-19/h4-5,8-9,13-15,17,22,24-27,33-34H,6-7,10-12,16H2,1-3H3/t22-,24+,25-,26-,27-,28-,29-,30-/m1/s1;
InChIKey	KSGZCKSNTAJOJS-DZBMUNJRBJ
ChEBI	67171
性质
化学式	C30H36N2O3
摩尔质量	472.62 g·mol−1
密度	1.30±0.1 g·cm-3（20 °C）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

皮质抑素A是一种海洋类固醇天然产物，2006年在海绵 Corticium simplex生物体中分离而取得^[2]^[3]。香港大学Pauline Chiu（赵宝贻）等人对其全合成方法进行了报道，其研究显示皮质抑素A可以有助减缓肿瘤的生长。^[4]

参考文献

^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-06-20].
^ Aoki, S; Watanabe, Y; Sanagawa, M; Setiawan, A; Kotoku, N; Kobayashi, M. Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.. Journal of the American Chemical Society. 2006-03-15, 128 (10): 3148–9. PMID 16522087. doi:10.1021/ja057404h.
^ Shenvi, Ryan A.; Guerrero, Carlos A.; Shi, Jun; Li, Chuang-Chuang; Baran, Phil S. Synthesis of (+)-Cortistatin A. Journal of the American Chemical Society. 2008-06, 130 (23): 7241–7243. doi:10.1021/ja8023466.
^ Kuang, Liping; Liu, Lok Lok; Chiu, Pauline. Formal Total Synthesis of (+)-Cortistatins A and J. Chemistry - A European Journal. 2015-10-05, 21 (41): 14287–14291. doi:10.1002/chem.201502890.