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溴朵林

維基百科,自由的百科全書
溴朵林
臨床資料
其他名稱Bromadoline
ATC碼
  • 未分配
識別資訊
  • 4-bromo-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]benzamide
CAS號67579-24-2  checkY
PubChem CID
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C15H21BrN2O
摩爾質量325.25 g·mol−1
3D模型(JSmol英語JSmol
  • CN(C)[C@@H]1CCCC[C@H]1NC(=O)C2=CC=C(C=C2)Br
  • InChI=1S/C15H21BrN2O/c1-18(2)14-6-4-3-5-13(14)17-15(19)11-7-9-12(16)10-8-11/h7-10,13-14H,3-6H2,1-2H3,(H,17,19)/t13-,14-/m1/s1
  • Key:UFDJFJYMMIZKLG-ZIAGYGMSSA-N

溴朵林(U-47931E)[1]是一種有機化合物,化學式為C15H21BrN2O,它是Upjohn公司於1970年代研發[2]的對μ-阿片受體具有選擇性的類阿片鎮痛藥[3]其藥效介於可待因和嗎啡之間,略強於噴他佐辛[4]

參見

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參考文獻

[編輯]
  1. ^ Unlisted Drugs 34–35. Chatham: Pharmaceutical Section, Special Libraries Association. 1982: 392. ISBN 978-0-913210-13-0. 
  2. ^ Jacob Szmuszkovicz. Patent US4098904 - Analgesic N-(2-aminocycloaliphatic)benzamides. The Upjohn Company. 4 July 1978 [2023-09-22]. (原始內容存檔於2016-10-26). 
  3. ^ Hayes AG, Skingle M, Tyers MB. Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine. The Journal of Pharmacology and Experimental Therapeutics. March 1987, 240 (3): 984–8. PMID 3559988. 
  4. ^ Hayes AG, Sheehan MJ, Tyers MB. Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists. British Journal of Pharmacology. August 1987, 91 (4): 823–32. PMC 1853585可免費查閱. PMID 2822190. doi:10.1111/j.1476-5381.1987.tb11281.x.