皮質抑素A
外觀
(重新導向自Cortistatin A)
皮質抑素A | |
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IUPAC名 (1R,2R,3S,5R,8β,17β)-3-(Dimethylamino)-17-(isoquinolin-7-yl)-5,8-epoxy-9,19-cyclo-9,10-secoandrosta-9(11),10-diene-1,2-diol | |
別名 | Cortistatine A |
識別 | |
CAS號 | 882976-95-6 ![]() |
PubChem | 11561907 |
ChemSpider | 9736681 |
SMILES |
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InChI |
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InChIKey | KSGZCKSNTAJOJS-DZBMUNJRBJ |
ChEBI | 67171 |
性質 | |
化學式 | C30H36N2O3 |
摩爾質量 | 472.62 g·mol−1 |
密度 | 1.30±0.1 g·cm-3(20 °C)[1] |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
皮質抑素A是一種海洋類固醇天然產物,2006年在海綿 Corticium simplex生物體中分離而取得[2][3]。香港大學Pauline Chiu(趙寶貽)等人對其全合成方法進行了報道,其研究顯示皮質抑素A可以有助減緩腫瘤的生長。[4]
參考文獻
[編輯]- ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-06-20].
- ^ Aoki, S; Watanabe, Y; Sanagawa, M; Setiawan, A; Kotoku, N; Kobayashi, M. Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.. Journal of the American Chemical Society. 2006-03-15, 128 (10): 3148–9. PMID 16522087. doi:10.1021/ja057404h.
- ^ Shenvi, Ryan A.; Guerrero, Carlos A.; Shi, Jun; Li, Chuang-Chuang; Baran, Phil S. Synthesis of (+)-Cortistatin A. Journal of the American Chemical Society. 2008-06, 130 (23): 7241–7243. doi:10.1021/ja8023466.
- ^ Kuang, Liping; Liu, Lok Lok; Chiu, Pauline. Formal Total Synthesis of (+)-Cortistatins A and J. Chemistry - A European Journal. 2015-10-05, 21 (41): 14287–14291. doi:10.1002/chem.201502890.