邁耶斯合成
邁耶斯合成（英語：Meyers synthesis），得名於美國化學家艾伯特·I·邁耶斯，指通過噁嗪水解製取不對稱醛類。[1][2][3][4]
2-取代的二氫-1,3-噁嗪的α-氫被強鹼（如丁基鋰）奪取，生成的碳負離子被鹵代烴烷化，然後硼氫化鈉將碳氮雙鍵還原，最後在草酸水溶液中水解，半縮胺轉變為醛。
參見
[編輯]參考資料
[編輯]- ^ Aldehydes from dihydro-1,3-oxazines. I. Synthesis of aliphatic aldehydes and their C-1 deuterated derivatives Albert I. Meyers, Aiko Nabeya, H. Wayne Adickes, Ieva R. Politzer J. Am. Chem. Soc. 1969; 91(3); 763-764. doi:10.1021/ja01031a053
- ^ Aldehydes from dihydro-1,3-oxazines. II. Synthesis of .alpha.,.beta.-unsaturated aldehydes and their C-1 deuterated derivatives Albert I. Meyers, Aiko Nabeya, H. Wayne Adickes, J. Michael Fitzpatrick, G. Ray Malone, and Ieva R. Politzer pp 764 - 765; J. Am. Chem. Soc. 1969 {{DOI:10.1021/ja01031a054}}
- ^ Aldehydes from dihydro-1,3-oxazines. III. Synthesis of cycloalkanecarboxaldehydes Albert I. Meyers, H. Wayne Adickes, Ieva R. Politzer, and Warren N. Beverung pp 765 - 767; J. Am. Chem. Soc. 1969 doi:10.1021/ja01031a055
- ^ Organic Syntheses, Coll. Vol. 6, p.905 (1988); Vol. 51, p.24 (1971). http://www.orgsynth.org/orgsyn/pdfs/CV6P0905.pdf （頁面存檔備份，存於互聯網檔案館）