FK962
外觀
識別資訊 | |
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CAS號 | 283167-06-6 |
PubChem CID | |
ChemSpider | |
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ChEMBL | |
化學資訊 | |
化學式 | C14H17FN2O2 |
摩爾質量 | 264.30 g·mol−1 |
3D模型(JSmol) | |
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FK962是一種有機化合物,可用作體抑素釋放的促進劑。它可以刺激神經生長和神經突伸長,並已在動物模型中進行了研究,在阿茲海默症和視神經病變等疾病的治療上具有潛在應用。[1][2][3][4]
參考文獻
[編輯]- ^ Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. European Journal of Pharmacology. December 2005, 527 (1–3): 111–120. PMID 16325809. doi:10.1016/j.ejphar.2005.10.022.
- ^ McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. March 2011, 98 (1): 76–80. PMID 21130801. S2CID 26055819. doi:10.1016/j.pbb.2010.11.019.
- ^ Kishimoto Y, Yabuta C, Shearer TR, Azuma M. FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF. Investigative Ophthalmology & Visual Science. August 2012, 53 (9): 5312–5319. PMID 22714891. doi:10.1167/iovs.11-8957.
- ^ Nakajima E, Walkup RD, Shearer TR, Azuma M. FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. January 2017, 255 (1): 107–112. PMID 27778122. S2CID 26043647. doi:10.1007/s00417-016-3525-5.