西那西呱
外觀
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臨床資料 | |
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給藥途徑 | 靜脈注射 (?) |
ATC碼 |
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識別資訊 | |
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CAS號 | 329773-35-5 ![]() |
PubChem CID | |
IUPHAR/BPS | |
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ChEBI | |
CompTox Dashboard (EPA) | |
化學資訊 | |
化學式 | C36H39NO5 |
摩爾質量 | 565.71 g·mol−1 |
3D模型(JSmol) | |
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西那西呱(INN:cinaciguat;開發代號:BAY 58-2667)是一種實驗性可溶性鳥苷酸環化酶激活劑,設計用於治療急性失代償性心力衰竭。[1][2]該藥物能提高環磷酸鳥苷的產量進而引起肺血管舒張。[3][4]
參考資料
[編輯]- ^ Gheorghiade, Mihai; Greene, Stephen J.; Filippatos, Gerasimos; Erdmann, Erland; Ferrari, Roberto; Levy, Phillip D.; Maggioni, Aldo; Nowack, Christina; Mebazaa, Alexandre; COMPOSE Investigators and Coordinators. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. European Journal of Heart Failure. 2012-09, 14 (9). ISSN 1879-0844. PMID 22713287. doi:10.1093/eurjhf/hfs093.
- ^ Erdmann, Erland; Semigran, Marc J.; Nieminen, Markku S.; Gheorghiade, Mihai; Agrawal, Rahul; Mitrovic, Veselin; Mebazaa, Alexandre. Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure. European Heart Journal. 2013-01, 34 (1). ISSN 1522-9645. PMID 22778174. doi:10.1093/eurheartj/ehs196.
- ^ Chester, Marc; Seedorf, Gregory; Tourneux, Pierre; Gien, Jason; Tseng, Nancy; Grover, Theresa; Wright, Jason; Stasch, Johannes-Peter; Abman, Steven H. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2011-11, 301 (5). ISSN 1522-1504. PMC 3213988
. PMID 21856817. doi:10.1152/ajplung.00138.2010.
- ^ Chester, Marc; Tourneux, Pierre; Seedorf, Greg; Grover, Theresa R.; Gien, Jason; Abman, Steven H. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2009-08, 297 (2). ISSN 1522-1504. PMC 2742799
. PMID 19465519. doi:10.1152/ajplung.00062.2009.