入地蜈蚣素K

入地蜈蚣素K
英文名	Ugonin K
识别
CAS号	651304-98-2
SMILES	OC1=C2C(OC(=CC2=O)C3=CC(O)=C(O)C=C3)=CC(OC)=C1C[C@@H]4C(C)(C)CCCC4=C;
性质
化学式	C26H28O6
摩尔质量	436.5 g·mol−1
外观	黄色固体
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

入地蜈蚣素K是一种有机化合物，化学名为2-(3,4-二羟基苯基)-6[(1R)-2,2-二甲基-6-亚甲基环己基]甲基5-羟基-7-甲氧基-4H-1-苯并吡喃-4-酮，化学式为C₂₆H₂₈O₆。它是从七指蕨分离出的黄酮类化合物之一。^[1]它具有中等程度的抗糖尿病活性（IC₅₀=138.21±0.263 ppm）；^[2]它也对RAW264.7（捷克语：Buněčná linie RAW 264.7）细胞中RANKL诱导的破骨细胞分化表现出抑制活性（IC₅₀=1.8±0.2 μM）。^[3]

参考文献

^ ^1.0 ^1.1 Yu-Ling Huang, Pei-Yu Yeh, Chien-Chang Shen, Chien-Chih Chen. Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica. Phytochemistry, 2003. 64 (7). 1277-1283. doi:10.1016/j.phytochem.2003.09.009.
^ Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, and Hilwan Yuda Teruna. Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacognosy Journal, 2020, 12, 2, 223-226. doi:10.5530/pj.2020.12.33.
^ Yu-Ling Huang; et al. Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod. 2017, 80, 2, 246–253. doi:10.1021/acs.jnatprod.5b01164.

[Huang-1] 1.0 ^1.1 Yu-Ling Huang, Pei-Yu Yeh, Chien-Chang Shen, Chien-Chih Chen. Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica. Phytochemistry, 2003. 64 (7). 1277-1283. doi:10.1016/j.phytochem.2003.09.009.

[2] Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, and Hilwan Yuda Teruna. Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacognosy Journal, 2020, 12, 2, 223-226. doi:10.5530/pj.2020.12.33.

[3] Yu-Ling Huang; et al. Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod. 2017, 80, 2, 246–253. doi:10.1021/acs.jnatprod.5b01164.

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