噻二唑

噻二唑是唑类化合物的一个亚族，噻二唑的名称源自汉奇-威德曼命名法。从结构上看，它们是含有1个硫原子和2个氮原子的五元杂环化合物。它们由于两个双键和硫孤对而成为芳香环。根据杂原子的相对位置，存在四种可能的结构；这些形式不会相互转化，因此是结构异构体而不是互变异构体。这些化合物本身很少被合成并且没有特殊的应用，然而，以它们作为结构基序的化合物在药理学中相当常见。 1,3,4-噻二唑是最常见的，出现在头孢唑啉和乙酰唑胺等药物中。^[1]^[2]^[3]

参考资料

^ Hu, Yang; Li, Cui-Yun; Wang, Xiao-Ming; Yang, Yong-Hua; Zhu, Hai-Liang. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry. Chemical Reviews. 2014, 114 (10): 5572–5610. ISSN 0009-2665. PMID 24716666. doi:10.1021/cr400131u.
^ Jain, Abhishek Kumar; Sharma, Simant; Vaidya, Ankur; Ravichandran, Veerasamy; Agrawal, Ram Kishore. 1,3,4-Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities. Chemical Biology & Drug Design. 2013, 81 (5): 557–576. ISSN 1747-0277. PMID 23452185. doi:10.1111/cbdd.12125 .
^ Wim Dehaen; Vasiliy A. Bakulev; Edward C. Taylor; Jonathan A. Ellman. The Chemistry of Heterocyclic Compounds, The Chemistry of 1,2,3-Thiadiazoles. John Wiley & Sons. 27 April 2004: 5–. ISBN 978-0-471-65691-3.

[HuLi2014-1] Hu, Yang; Li, Cui-Yun; Wang, Xiao-Ming; Yang, Yong-Hua; Zhu, Hai-Liang. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry. Chemical Reviews. 2014, 114 (10): 5572–5610. ISSN 0009-2665. PMID 24716666. doi:10.1021/cr400131u.

[JainSharma2013-2] Jain, Abhishek Kumar; Sharma, Simant; Vaidya, Ankur; Ravichandran, Veerasamy; Agrawal, Ram Kishore. 1,3,4-Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities. Chemical Biology & Drug Design. 2013, 81 (5): 557–576. ISSN 1747-0277. PMID 23452185. doi:10.1111/cbdd.12125 .

[DehaenBakulev2004-3] Wim Dehaen; Vasiliy A. Bakulev; Edward C. Taylor; Jonathan A. Ellman. The Chemistry of Heterocyclic Compounds, The Chemistry of 1,2,3-Thiadiazoles. John Wiley & Sons. 27 April 2004: 5–. ISBN 978-0-471-65691-3.

[1]

[2]

[3]