AR-R17779
外觀
AR-R17779 | |
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IUPAC名 (2S)-4′-Azaspiro[bicyclo[2.2.2]octane-2,5′-[1,3]oxazolidin]-2′-one | |
別名 | (−)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one] |
識別 | |
CAS號 | 178419-47-1 ![]() |
PubChem | 5310971 |
ChemSpider | 4470515 |
SMILES |
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InChI |
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ChEBI | CHEBI:420311 |
性質 | |
化學式 | C9H14N2O2 |
摩爾質量 | 182.22 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
AR-R17779,分子式C9H14N2O2,是α7菸鹼型乙醯膽鹼受體的完全激動劑[1][2]。
參考文獻
[編輯]- ^ Mullen, G.; Napier, A.; Balestra, M.; Decory, T.; Hale, G.; Macor, J.; Mack, R.; Loch, J.; Wu, E.; Kover, A.; Verhoest, P.; Sampognaro, A.; Phillips, E.; Zhu, Y.; Murray, R.; Griffith, R.; Blosser, J.; Gurley, D.; Machulskis, A.; Zongrone, J.; Rosen, A.; Gordon, J. (−)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 2000, 43 (22): 4045–4050. PMID 11063601. doi:10.1021/jm000249r.
- ^ Macor, J.; Mullen, G.; Verhoest, P.; Sampognaro, A.; Shepardson, B.; Mack, R. A chiral synthesis of (−)-spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one]: A conformationally restricted analogue of acetylcholine that is a potent and selective α7 nicotinic receptor agonist. The Journal of Organic Chemistry. 2004, 69 (19): 6493–6495. PMID 15357617. doi:10.1021/jo049404q.
外部連結
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