Opiorphin
外觀
Opiorphin[1] | |
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IUPAC名 (2S,5S,8S,11S,14S)-14,17-diamino-8-benzyl-2,11-bis(3-guanidinopropyl)-5-(hydroxymethyl)-4,7,10,13,17-pentaoxo-3,6,9,12-tetraazaheptadecan-1-oic acid | |
別名 | Gln-Arg-Phe-Ser-Arg; L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine |
識別 | |
CAS號 | 864084-88-8 ![]() |
PubChem | 25195667 |
ChemSpider | 28296048 |
SMILES |
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InChI |
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InChIKey | TWWFCOBVAKAKIT-SXYSDOLCBM |
性質 | |
化學式 | C29H48N12O8 |
摩爾質量 | 692.77 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
Opiorphin是一種首先從人類唾液中分離出來的內源性化合物。對小鼠的初步研究表明,該化合物的止痛效果高於嗎啡[2]。它的止痛機制是阻止腦啡肽(脊髓中的天然止痛阿片類藥物)的正常分解。它由五個胺基酸多肽Gln - Arg - Phe - Ser -Arg (QRFSR) 組成,是一種相對簡單的分子。[3][4][5][6][7][8][9][10]
參考資料
[編輯]- ^ Opiorphin (頁面存檔備份,存於網際網路檔案館) at Sigma-Aldrich
- ^ Rougeot C, Robert F, Menz L, Bisson JF, Messaoudi M. Systemically active human opiorphin is a potent yet non-addictive analgesic without drug tolerance effects. J. Physiol. Pharmacol. August 2010, 61 (4): 483–90. PMID 20814077.
- ^ Dickinson DP, Thiesse M. cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein. Curr. Eye Res. April 1996, 15 (4): 377–86. PMID 8670737. doi:10.3109/02713689608995828.
- ^ Andy Coghlan. Natural-born painkiller found in human saliva. New Scientist. November 13, 2006. (原始內容存檔於2007-01-27).
- ^ Natural chemical 'beats morphine'. BBC News. November 14, 2006 [2022-07-31]. (原始內容存檔於2022-03-24).
- ^ Mary Beckman. Prolonging Painkillers. ScienceNOW. November 13, 2006 [2022-07-31]. (原始內容存檔於2007-12-12).
- ^ Stanović S, Boranić M, Petrovecki M, et al. Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission. Haematologia (Budap). 2000, 30 (1): 1–10. PMID 10841318. doi:10.1163/15685590051129814.
- ^ Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. October 2008, 9 (10): 887–94. PMID 18855623. doi:10.2174/138945008785909356.
- ^ Davies KP. The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology. J Sex Med. March 2009,. 6 Suppl 3: 286–91. PMC 2864530
. PMID 19267851. doi:10.1111/j.1743-6109.2008.01186.x.
- ^ Tian XZ, Chen J, Xiong W, He T, Chen Q. Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides. July 2009, 30 (7): 1348–54. PMID 19442408. S2CID 32291165. doi:10.1016/j.peptides.2009.04.002.
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