墨菲罗斯大鼠
墨菲罗斯大鼠（Murphy Roths Large）是在1999年发现的具有显著的组织再生能力的小家鼠。[1][2][3]
研究
[编辑]墨菲罗斯大鼠是小鼠属中表现再生能力最强的品种。正在研究这些动物并试图把这种能力应用到人类身上。
通过比较愈合良好的MRL鼠和愈合不良的C57BL/6鼠的基因表现差异，已经确定36个基因用于决定这种愈合能力[4][5]。
MRL鼠的再生能力保护他们免于心肌梗死，成年哺乳动物心肌细胞的再生是十分局限的，因为心脏的心肌细胞几乎都处于G0期，即终末分化期。MRL鼠在心脏病发作后同一般的鼠类的心肌损伤和瘢痕组织数几乎一样[6]，然而，根据最新的研究证明，这种情况并非永远如此，心脏损伤后的MRL小鼠能够再生损伤部位的组织[7]。
参考资料
[编辑]- ^ Heber-Katz, E; Leferovich, JM; Bedelbaeva, K; Gourevitch, D. Spallanzani's mouse: a model of restoration and regeneration. Current topics in microbiology and immunology. 2004, 280: 165–89. PMID 14594211.
- ^ BBC News: Mouse sheds light on regeneration （页面存档备份，存于互联网档案馆）, 11 April 2006, By Rebecca Morelle, BBC News
- ^ ScienCentral: Self-Healing Mice 互联网档案馆的存檔，存档日期2008-10-20., 2006/04/18, by Lindsay Carswell, ScienCentral News
- ^ Masinde G, Li X, Baylink DJ, Nguyen B, Mohan S. Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice. Biochemical and Biophysical Research Communications. April 2005, 330 (1): 117–22. PMID 15781240. doi:10.1016/j.bbrc.2005.02.143.
- ^ Mansuo L. Hayashi, B. S. Shankaranarayana Rao, Jin-Soo Seo, Han-Saem Choi, Bridget M. Dolan, Se-Young Choi, Sumantra Chattarji, and Susumu Tonegawa. Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proceedings of the National Academy of Sciences. 2007 July, 104 (27): 11489–94. PMC 1899186
. PMID 17592139. doi:10.1073/pnas.0705003104.
- ^ Abdullah I, Lepore JJ, Epstein JA, Parmacek MS, Gruber PJ. MRL mice fail to heal the heart in response to ischemia-reperfusion injury. Wound Repair Regen. 2005 Mar-April, 13 (2): 205–208. PMID 15828946. doi:10.1111/j.1067-1927.2005.130212.x.
- ^ Regeneration in the mammalian heart demonstrated by Wistar researchers. [2014-02-27]. （原始内容存档于2018-12-15）.
