English: Frequency of YDNA haplogroup E in modern populations and hypothetical migration route from its ancestor clade DE in Central Asia.

Haplogroup E was birth in Africa about 77,000 years ago (~75,000 BC).

Haplogroup DE migrated into Africa as part of a massive migration. ( Haplogroup DE, next to CF, were the Basal-Eurasian lineages which expanded from the Middle East. The common ancestral lineage ("YDNA Adam") is suggested to have originated somewhere in the Middle East or the Iranian Plateau (per Arnason et al. 2020 "The reversal of human phylogeny: Homo left Africa as erectus, came back as sapiens sapiens" ^[1]).

Massive African migration and following admixture created the many different Eurasian populations of today. "We find evidence for substantial migration from the ancestors of present-day African into Eurasia groups about 70 thousand years ago. This event accounts for previously unexplained genetic diversity in African populations, and supports the existence of novel population substructure in the Late Middle Paleolithic. Our results indicate that our species' demographic history around the out-of-Africa event is more complex than previously appreciated." In other words, modern African people (Sub-Saharan Africans) formed from indigenous Paleo-African groups and intrusive Eurasians (Basal-Eurasians and Ancient North Africans). Finally, there is the fact Y haplogroup E is nowadays dominant among non-hunter-gatherers in Africa, and it is within the “Eurasian-clade” DE, while indigenous African hunter gatherers belong to haplogroups A, A00 and B (per Cole et al. 2021 (under reviewing 2020) "Ancient Admixture into Africa from the ancestors of non-Africans"^[2], and see also "Massive “Basal Eurasian” Back-Migration"^[3]).