纖維細胞:修订间差异

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2020年1月16日 (四) 08:45的版本

纖維細胞(fibrocyte)是一種沒有活性的間充質細胞,細胞顯示出體積小的細胞質、數量有限的粗糙內質網,並且缺乏蛋白質合成的生化證據。

纖維細胞與成纖維細胞並不一樣。成纖維細胞是已活化的結締組織細胞,擁有能夠合成纖維基質的蛋白質(尤其是膠原蛋白)是它的特徵。當組織損傷時,成纖維細胞會源自於纖維細胞,抑或源自於血管和腺體內的平滑肌細胞。成纖維細胞通常表達着平滑肌肌動蛋白,這是一種首先在平滑肌細胞中被發現,並且不見於休眠纖維細胞的肌動蛋白形式。表達這種肌動蛋白形式的成纖維細胞通常被稱為肌成纖維細胞(myo-fibroblasts)。纖維細胞即代表一些能夠離開血液且進入身體組織,成為成纖維細胞的血源細胞(bloodborne cell )。作為幹細胞生物學的一部分,許多研究表明血液中含有源自骨髓的細胞,這些細胞可以分化為成纖維細胞。據報導這些細胞表達造血細胞表面標記CD34[1]蛋白酪氨酸磷酸酶C型受體及膠原蛋白。除此之外,這些細胞可以遷移到存在傷口的部位,並且因細胞在皮膚瘢痕組織中的免疫定位,而提示其在傷口癒合中的作用[2][3]。一般認為纖維細胞介導着傷口癒合和纖維化組織修復[4][5],甚至誘導血管的生成[6]

參考資料

  1. ^ Yang, L; Scott, PG; Giuffre, J; Shankowsky, HA; Ghahary, A; Tredget, EE. Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells.. Laboratory investigation; a journal of technical methods and pathology. 2002-09, 82 (9): 1183–92 [2020-01-16]. PMID 12218079. doi:10.1097/01.lab.0000027841.50269.61. 
  2. ^ Bucala, R; Spiegel, LA; Chesney, J; Hogan, M; Cerami, A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair.. Molecular medicine (Cambridge, Mass.). 1994-11, 1 (1): 71–81 [2020-01-16]. PMID 8790603. 
  3. ^ Chesney, J; Bacher, M; Bender, A; Bucala, R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ.. Proceedings of the National Academy of Sciences of the United States of America. 1997-06-10, 94 (12): 6307–12 [2020-01-16]. PMID 9177213. doi:10.1073/pnas.94.12.6307. 
  4. ^ Chesney, J; Metz, C; Stavitsky, AB; Bacher, M; Bucala, R. Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes.. Journal of immunology (Baltimore, Md. : 1950). 1998-01-01, 160 (1): 419–25 [2020-01-16]. PMID 9551999. 
  5. ^ Grab, DJ; Lanners, H; Martin, LN; Chesney, J; Cai, C; Adkisson, HD; Bucala, R. Interaction of Borrelia burgdorferi with peripheral blood fibrocytes, antigen-presenting cells with the potential for connective tissue targeting.. Molecular medicine (Cambridge, Mass.). 1999-01, 5 (1): 46–54 [2020-01-16]. PMID 10072447. 
  6. ^ Hartlapp, I; Abe, R; Saeed, RW; Peng, T; Voelter, W; Bucala, R; Metz, CN. Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2001-10, 15 (12): 2215–24 [2020-01-16]. PMID 11641248. doi:10.1096/fj.01-0049com.