三甲基三氟甲基硅烷

三甲基三氟甲基硅烷
	IUPAC名; Trimethyl(trifluoromethyl)silane
别名	Ruppert's reagent; TFMTMS; CF3SiMe3
识别
CAS号	81290-20-2
PubChem	552549
ChemSpider	480635
SMILES	C[Si](C)(C)C(F)(F)F;
性质
化学式	C4H9F3Si
摩尔质量	142.19 g·mol−1
外观	无色液体
密度	0.9626 g/cm3 at 20 °C
沸点	54 ~ 55 °C
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

三甲基三氟甲基硅烷（Ruppert-Prakash试剂，TMSCF₃）是一种有机硅化合物，化学式为CF₃Si(CH₃)₃。它是无色液体，在有机合成中可用于引入三氟甲基。它最初于1984年由Ingo Ruppert合成，^[1]并在后来由G. K. Surya Prakash进一步研究了它在有机合成中的应用。^[2]^[3]

参考文献[编辑]

^ Ruppert, Ingo; Schlich, Klaus; Volbach, Wolfgang. Fluorinated organometallic compounds. 18. First trifluoromethyl-substituted organyl(chloro)silanes. Tetrahedron Letters. 1984, 25 (21): 2195–2198. doi:10.1016/S0040-4039(01)80208-2.
^ Prakash, G. K. Surya; Yudin, Andrei K. Perfluoroalkylation with Organosilicon Reagents. Chemical Reviews. 1997-05-01, 97 (3): 757–786. ISSN 0009-2665. PMID 11848888. doi:10.1021/cr9408991.
^ Liu, Xiao; Xu, Cong; Wang, Mang; Liu, Qun. Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond. Chemical Reviews. 2015-01-28, 115 (2): 683–730. ISSN 0009-2665. PMID 24754488. doi:10.1021/cr400473a.

[1] Ruppert, Ingo; Schlich, Klaus; Volbach, Wolfgang. Fluorinated organometallic compounds. 18. First trifluoromethyl-substituted organyl(chloro)silanes. Tetrahedron Letters. 1984, 25 (21): 2195–2198. doi:10.1016/S0040-4039(01)80208-2.

[2] Prakash, G. K. Surya; Yudin, Andrei K. Perfluoroalkylation with Organosilicon Reagents. Chemical Reviews. 1997-05-01, 97 (3): 757–786. ISSN 0009-2665. PMID 11848888. doi:10.1021/cr9408991.

[3] Liu, Xiao; Xu, Cong; Wang, Mang; Liu, Qun. Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond. Chemical Reviews. 2015-01-28, 115 (2): 683–730. ISSN 0009-2665. PMID 24754488. doi:10.1021/cr400473a.

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