傅嫈惠

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傅嫈惠
Ying-Hui Fu
居住地  美國加利福尼亚州旧金山
配偶 Louis Ptáček
网站 http://www.neugenes.org/outreach.htm
科学生涯
研究領域 神经科学
遗传学
Neuroscience of sleep
机构 加州大学旧金山分校

傅嫈惠生物学家人类遗传学家,目前是加州大学旧金山分校的神经学教授。2018年,她当选为美国国家科学院院士。[1]

经历[编辑]

1980年,傅嫈惠在国立中兴大学获得食品科学学位。1986年,她毕业于俄亥俄州立大学,获得生物化学以及细胞生物学学位。之后,傅嫈惠在俄亥俄州立大学和贝勒医学院从事了博士后研究,主要研究内容为人类基因组。她在业界工作过四年后,返回学术界,担任犹他大学研究助理教授。2002年,她在加州大学旧金山分校与合作者Louis Ptacek共同组建了实验室。

部分出版物[编辑]

  1. Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptáček LJ, Fu Y-H. An hPer2 phosphorylation site mutation in familial advanced sleep-phase syndrome. Science. 2001;291:1040-3.
  2. Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptáček LJ, Fu Y-H. Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome. Nature. 2005;434:640-4.
  3. Padiath QS, Saigoh K, Schiffman R, Asahara H, Koeppen A, Hogan K, Ptáček LJ, Fu Y-H. Lamin B1duplications cause autosomal dominant leukodystrophy. Nat Genet. 2006 Oct ; 38(10)1114-23. Epub 2006 Sep 3.
  4. He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.
  5. Fu, YH and Marzluf, GA. cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. J Biol Chem, 1990, 265, 11942-11947.
  6. Fu, Y.H., Kuhl, D.P., Pizzuti, et al. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell, 1991, 67, 1047-1058.
  7. Fu, Y.H., Pizzuti, A., Fenwick, R.G., Jr., et al. An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science, 1992, 255, 1256-1258.
  8. Yu, C.E., Oshima, J., Fu, Y.H., et al. Positional cloning of the Werner's syndrome gene. Science, 1996, 272, 258-262.
  9. Levy‑Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wejsman EM, Bird TD, Schellenberg GD, Tanzi RE. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science, 1995 269, 973-977.
  10. Xu Y, Toh KL, Jones CR, Shin JY, Fu Y-H*, Ptáček LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. 2007 Jan 12:128(1):59-70.
  11. Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu Y-H*. Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock.Cell Metab. 2013 Feb 5;17(2):291-302.
  12. Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ. Casein kinase iδ Mutations in Familial Migraine and Advanced Sleep Phase.Science Transitional Mag. 2013 May 1; 183(5):183ra56.
  13. He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.
  14. Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5; 17(2):291-302. PubMed; 位於PMC的全文本內容:3597447.

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