开普敦大学（英語：University of Cape Town；南非語：Universiteit van Kaapstad；科薩語：iYunivesithi yaseKapa）是位于南非开普敦的一所公立研究型大学。该校创办于1829年，原名南非学院（South African College）。它是南非最古老的大学，并且是非洲第二古老的现存大学。[來源請求]该校的教学语言是英语，校友中共有5位诺贝尔奖得主。
Ralph Bunche, American political scientist and diplomat awarded the Nobel Peace Prize in 1950 for his role in the 1949 Armistice Agreements.
Max Theiler, virologist awarded the Nobel Prize in Physiology or Medicine in 1951 for developing a vaccine against yellow fever.
Professor Allan McLeod Cormack, physicist awarded the Nobel Prize in Medicine (1979) for his work on X-ray computed tomography
Sir Aaron Klug, chemist and biophysicist awarded the Nobel Prize in Chemistry (1982) for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes
Professor Emeritus J. M. Coetzee (Literature, 2003)