EBC-1

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EBC-1人類鱗狀細胞癌細胞系[1]。EBC-1細胞具有Met基因英语C-Met (一種肝細胞生長因子英语Hepatocyte growth factor受體) 顯著擴增及過度表達Met受體的特徵,這些受體持續地被磷酸化,並且發現β-連環蛋白英语Beta-cateninp120英语CTNND1/δ-連環蛋白英语Delta catenin磷酸化酪氨酸的上升趨勢[2]小髮夾RNA介導的Met基因敲落在EBC-1細胞中,顯著誘導着生長的抑制細胞凋亡,而其對沒有Met基因擴增的細胞系幾乎沒有任何影響。這些實驗結果表明Met基因的擴增,可以鑑定出對靶向Met基因的新分子療法 (molecular therapies) ,存在反應的非小細胞肺癌英语Non-small-cell lung carcinoma子集[2]

參考資料[编辑]

  1. ^ KIMURA, MICHITAKA; NAITO, HIROSHI; TOJO, TAKASHI; ITAYA-HIRONAKA, ASAKO; DOHI, YOSHIKO; YOSHIMURA, MAMIKO; NAKAGAWARA, KAN-ICHI; TAKASAWA, SHIN; TANIGUCHI, SHIGEKI. REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms. Oncology Reports. 2013-12, 30 (6): 2625–2631. doi:10.3892/or.2013.2739. 
  2. ^ 2.0 2.1 Lutterbach, B; Zeng, Q; Davis, LJ; Hatch, H; Hang, G; Kohl, NE; Gibbs, JB; Pan, BS. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival.. Cancer research. 2007-03-01, 67 (5): 2081–8 [2019-12-24]. PMID 17332337. doi:10.1158/0008-5472.CAN-06-3495. (原始内容存档于2019-12-24). 

外部連結[编辑]