PD-137889

PD-137889
	IUPAC名; (4aR)-N-Methyl-1,2,3,4,9,9a-hexahydro-4aH-fluoren-4a-amine
识别
CAS号	95372-93-3 ; 147128-60-7（rel-(4aR,9aS)）
PubChem	10104280
ChemSpider	8279807
SMILES	c12c(cccc1)C3(NC)CCCCC3C2;
InChI	1S/C14H19N/c1-15-14-9-5-4-7-12(14)10-11-6-2-3-8-13(11)14/h2-3,6,8,12,15H,4-5,7,9-10H2,1H3;
InChIKey	KQLIVVYSTDBTMZ-UHFFFAOYSA-N
性质
化学式	C14H19N
摩尔质量	201.31 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

PD-137889（N-甲基六氢芴胺）是一種化學化合物，中枢神经系统NMDA受体拮抗剂，效力比氯胺酮強約30倍^[1]，動物研究中可替代五氯苯酚。^[2]^[3]^[4]K_i[³H]TCP^[a] = 27 nM，氯胺酮K_i = 860 nM。 ^[5]

参考[编辑]

^ Hays, Sheryl J.; Novak, Perry M.; Ortwine, Daniel F.; Bigge, Christopher F.; Colbry, Norman L.; Johnson, Graham; Lescosky, Leonard J.; Malone, Thomas C.; Michael, Andre. Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor. J Med Chem. 1993, 36 (6): 654–70. PMID 8459395. doi:10.1021/jm00058a002.
^ Nicholson, Katherine L.; Balster, Robert L. Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats. Psychopharmacology. 2003, 170 (2): 215–224. PMID 2851738. S2CID 30803162. doi:10.1007/s00213-003-1527-6.
^ Bigge, Christopher F. Structural requirements for the development of potent n-methyl-d-aspartic acid (NMDA) receptor antagonists. Biochemical Pharmacology. 1993, 45 (8): 1547–1561. PMID 7683469. doi:10.1016/0006-2952(93)90294-7.
^ Bigge, Christopher F.; Malone, Thomas C. Overview: Agonists, Antagonists and Modulators of the N-methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) Subtypes of Glutamate Receptors. Current Opinion on Therapeutic Patents. 1993, 3 (7): 951–989. doi:10.1517/13543776.3.7.951.
^ Polycyclic amine derivatives useful as cerebrovascular agents （页面存档备份，存于互联网档案馆） United States Patent; Coughenour, et al. Family ID: 22686445 Appl. #07/186,834