SZ-685C

SZ-685C
英文名	Haloroquinone
别名	1,2,3,4-四氢-1,2,3,5,8-五羟基-6-甲氧基-3-甲基-9,10-蒽醌
识别
CAS号	1222440-09-6
SMILES	O=C1C2=C(O)C(OC)=CC(O)=C2C(=O)C3=C1CC(O)(C)C(O)C3O;
性质
化学式	C16H16O8
摩尔质量	336.29 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

SZ-685C是一种四氢蒽醌类的有机化合物，化学式为C₁₆H₁₆O₈。它可以通过Akt/FOXO途径诱导细胞凋亡，被用于抗肿瘤的研究。^[1]它的生物来源是一种海洋真菌Halorosellinia sp.（英语：Halorosellinia），因此该化合物也被称作“haloroquinone”。^[2]

参考文献[编辑]

^ Gui'e Xie, Xun Zhu, Qing Li, Minghui Gu, Zhenjian He, Jueheng Wu, Jun Li, Yongcheng Lin, Mengfeng Li, Zhigang She, Jie Yuan. SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. British Journal of Pharmacology. 2010. 159 (3): 689-697. doi:10.1111/j.1476-5381.2009.00577.x.
^ Chuanpeng Niu, Menghao Cai, Yuanxing Zhang & Xiangshan Zhou. Biosynthetic origin of the carbon skeleton of a novel anti-tumor compound, haloroquinone, from a marine-derived fungus, Halorosellinia sp. Biotechnology Letters, 2012. 34. 2119-2124. doi:10.1007/s10529-012-1019-z.

[1] Gui'e Xie, Xun Zhu, Qing Li, Minghui Gu, Zhenjian He, Jueheng Wu, Jun Li, Yongcheng Lin, Mengfeng Li, Zhigang She, Jie Yuan. SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. British Journal of Pharmacology. 2010. 159 (3): 689-697. doi:10.1111/j.1476-5381.2009.00577.x.

[2] Chuanpeng Niu, Menghao Cai, Yuanxing Zhang & Xiangshan Zhou. Biosynthetic origin of the carbon skeleton of a novel anti-tumor compound, haloroquinone, from a marine-derived fungus, Halorosellinia sp. Biotechnology Letters, 2012. 34. 2119-2124. doi:10.1007/s10529-012-1019-z.

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