Talk:谷氨酸脱羧酶

本条目页依照页面评级標準評為小作品级。
本条目页属于下列维基专题范畴：

（获评小作品級、低重要度）

	分子与细胞生物学主题查论编本条目页属于分子与细胞生物学专题范畴，该专题旨在改善中文维基百科分子與細胞生物學类内容。如果您有意参与，请浏览专题主页、参与讨论，并完成相应的开放性任务。
小作品	根据专题质量评级标准，本条目页已评为小作品级。
低	根据专题重要度评级标准，本條目已评为低重要度。

未翻譯內容

未翻譯內容如下：--Flame 歡迎泡茶 2011年6月19日 (日) 00:28 (UTC)[回复]

糖尿病

Both GAD₆₇ and GAD₆₅ are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes.^[1]^[2] Injections with GAD₆₅ has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.^[3]^[4]

精神分裂症与双相型障碍

GAD mRNA表达的大量失调，coupled with downregulation of reelin, is observed in 精神分裂症 and 双相障碍.^[5] The most pronounced downregulation of GAD67 was found in hippocampal stratum oriens layer in both disorders and in other layers and structures of hippocampus with varying degrees.^[6]

药物引起的改变

普瑞巴林，一种抗癫痫药, increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[1] Extracts from Centella asiatica (gotu kola) and Valeriana officinalis (valerian) stimulated GAD activity.^[7]

外部链接已修改

各位维基人：

我刚刚修改了谷氨酸脱羧酶中的1个外部链接，请大家仔细检查我的编辑。如果您有疑问，或者需要让机器人忽略某个链接甚至整个页面，请访问这个简单的FAQ获取更多信息。我进行了以下修改：

向 http://www.schizophreniaforum.org/new/detail.asp?id=1358 中加入存档链接 https://web.archive.org/web/20070815162255/http://www.schizophreniaforum.org/new/detail.asp?id=1358

有关机器人修正错误的详情请参阅FAQ。

祝编安。—InternetArchiveBot (報告軟件缺陷) 2017年7月22日 (六) 05:43 (UTC)[回复]

^ Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.
^ Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846 . PMID 1370298. doi:10.1172/JCI115573.
^ Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知参数|month=（建议使用|date=） (帮助)
^ Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].
^ Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.
^ Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575 . PMID 17553960. doi:10.1073/pnas.0703806104.
^ pmid18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知参数|month=（建议使用|date=） (帮助);

[pmid1697648-1] Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.

[pmid1370298-2] Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846 . PMID 1370298. doi:10.1172/JCI115573.

[pmid18843118-3] Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知参数|month=（建议使用|date=） (帮助)

[url_Diamyd-4] Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].

[pmid15237077-5] Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.

[pmid17553960-6] Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575 . PMID 17553960. doi:10.1073/pnas.0703806104.

[pmid18066140-7] 18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知参数|month=（建议使用|date=） (帮助);

[1]

[2]

[3]

[4]

[5]

[6]

[7]