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酮泛解酸

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酮泛解酸
别名 4-Hydroxy-3,3-dimethyl-2-oxobutanoic acid; 2-Dehydropantoic acid
识别
CAS号 470-30-4
PubChem 38
ChemSpider 37
SMILES
 
  • CC(C)(CO)C(=O)C(=O)O
Beilstein 2242422
ChEBI 17094
DrugBank DB03795
KEGG C00966
性质
化学式 C6H10O4
摩尔质量 146.14 g·mol−1
外观 colorless or white
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

酮泛解酸(英语:Ketopantoic acid)是一种有机化合物结构简式HOCH2(CH3)2CC(O)CO2H,结构上与泛解酸类似,属于Ω-羟基酮酸,在体内由α-酮异戊酸羟甲基化英语Hydroxymethylation生成,在生理条件英语Physiological condition下以共轭碱的形式存在[1][2]

参考文献

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  1. ^ Matak-Vinković, Dijana; Vinković, Mladen; Saldanha, S. Adrian; Ashurst, Jennifer L.; von Delft, Frank; Inoue, Tsuyoshi; Miguel, Ricardo Nunez; Smith, Alison G.; Blundell, Tom L.; Abell, Chris. Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism. Biochemistry. 2001, 40 (48): 14493–14500. PMID 11724562. doi:10.1021/bi011020w. 
  2. ^ Begley, Tadhg P.; Kinsland, Cynthia; Strauss, Erick. The Biosynthesis of Coenzyme a in Bacteria. Cofactor Biosynthesis. Vitamins & Hormones 61. 2001: 157–171. ISBN 9780127098616. PMID 11153265. doi:10.1016/S0083-6729(01)61005-7.