AM大麻素列表

美国马萨诸塞州东北大学亚历山德罗斯·马克里扬尼斯（Alexandros Makriyannis）的研究小组合成了许多大麻素，统称为AM大麻素，其中一些是：

大麻素及其K_i值(K_i是化合物对大麻素1型受体（CB₁）或大麻素2型受体（CB₂）的结合亲和力)
名称	类别	分子式	K_i/nM (CB₁)	K_i/nM (CB₂)	选择性	ref
AM-087	二苯并吡喃	C₂₃H₃₃BrO₂	0.43
AM-251	吡唑衍生物	C₂₂H₂₁Cl₂IN₄O	7.5			^[1]
AM-356		C₂₃H₃₉NO₂	17.9	868		^[2]
AM-404		C₂₆H₃₇NO₂
AM-411	二苯并吡喃	C₂₆H₃₄O₂	6.8	52.0
AM-630	苯甲酰基吲哚	C₂₃H₂₅IN₂O₃		32.1	CB₂(165×)
AM-678	萘甲酰基吲哚	C₂₄H₂₃NO	9.00±5.00	2.94±2.65	CB₂
AM-679	苯甲酰基吲哚	C₂₀H₂₀INO	13.5	49.5	CB₁
AM-694	苯甲酰基吲哚	C₂₀H₁₉FINO	0.08	1.44	CB₁(18×)	^[3]
AM-855		C₂₆H₃₈O₂	22.3	58.6	CB₁
AM-905		C₂₃H₃₄O₃	1.2	5.3	CB₁
AM-906		C₂₃H₃₄O₃	0.8	9.5	CB₁
AM-919		C₂₇H₄₄O₄	2.2	3.4	CB₁
AM-938		C₂₇H₄₀O₄	1.2	0.3	CB₂(4×)
AM-1220	萘甲酰基吲哚	C₂₆H₂₆N₂O	3.88	73.4	CB₁ (19×)	^[4]^[5]

参见

^ Lan, Ruoxi; Lu, Qian; Fan, Pusheng; Gatley, John; Volkow, Nora D.; Fernando, Susanthi R.; Pertwee, Roger; Makriyannis, Alexandros. Design and synthesis of the CB1 selective cannabinoid antagonist AM281: A potential human SPECT ligand. AAPS PharmSci. 1999, 1 (2): 39–45. PMC 2761119 . PMID 11741201. doi:10.1208/ps010204.
^ Selwood, D. The Cannabinoid Receptors. Edited by Patricia H. Reggio. ChemMedChem. 2009, 4: 1949. doi:10.1002/cmdc.200900286.
^ Template:Ref patent2
^ D'ambra, T. C-Attached aminoalkylindoles: potent cannabinoid mimetics. Bioorganic & Medicinal Chemistry Letters. 1996, 6: 17–22. doi:10.1016/0960-894X(95)00560-G.
^ Willis, P. G.; Pavlova, O. A.; Chefer, S. I.; Vaupel, D. B.; Mukhin, A. G.; Horti, A. G. Synthesis and Structure−Activity Relationship of a Novel Series of Aminoalkylindoles with Potential for Imaging the Neuronal Cannabinoid Receptor by Positron Emission Tomography. Journal of Medicinal Chemistry. 2005, 48 (18): 5813–22. PMID 16134948. doi:10.1021/jm0502743.