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2-丁基-3-(4-甲苯基)奎宁环

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2-丁基-3-(4-甲苯基)奎宁环
Skeletal formula of butyltolylquinuclidine
Ball-and-stick model of the butyltolylquinuclidine molecule
临床资料
ATC码
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法律规范状态
法律规范
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识别信息
  • (2R,3S,4S)-2-butyl-3-p-tolylquinuclidine
CAS号328047-48-9
PubChem CID
ChemSpider
UNII
化学信息
化学式C18H27N
摩尔质量257.42 g·mol−1
3D模型(JSmol英语JSmol
  • C3CC1CCN3C(CCCC)C1c(cc2)ccc2C
  • InChI=1S/C18H27N/c1-3-4-5-17-18(15-8-6-14(2)7-9-15)16-10-12-19(17)13-11-16/h6-9,16-18H,3-5,10-13H2,1-2H3
  • Key:QYIZEJQSBLRXJK-UHFFFAOYSA-N

2-丁基-3-(4-甲苯基)奎宁环(英语:2-Butyl-3-(p-tolyl)quinuclidine,Butyltolylquinuclidine,缩写BTQ)是一种具有兴奋剂功能的多巴胺再摄取抑制剂[1],是含奎宁环的药物之一,是治疗可卡因滥用的潜在药物之一[2],更加温和持久,在动物研究中产生与可卡因相似的效果。

参见

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参考文献

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  1. ^ Sakamuri S, Enyedy IJ, Zaman WA, Tella SR, Kozikowski AP, Flippen-Anderson JL, et al. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. March 2003, 11 (6): 1123–36. PMID 12614900. doi:10.1016/S0968-0896(02)00450-9. 
  2. ^ Enyedy IJ, Sakamuri S, Zaman WA, Johnson KM, Wang S. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. February 2003, 13 (3): 513–7. PMID 12565962. doi:10.1016/S0960-894X(02)00943-5.