7α-甲基雌二醇

7α-甲基雌二醇
临床资料
其他名称	7α-Methyl-E2; 7α-Me-E2; 7α-Methylestra-1,3,5(10)-triene-3,17β-diol
药物类别（英语：Drug class）	Estrogen
识别信息
	IUPAC命名法 (7R,8R,9S,13S,14S,17S)-7,13-Dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; ;
CAS号	10448-97-2
PubChem CID	10424124;
化学信息
化学式	C19H26O2
摩尔质量	286.42 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
熔点	120 °C（248 °F）
	SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=CC=C(O)C=C3C[C@@H](C)[C@@]21[H];
	InChI InChI=1/C19H26O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h3-4,10-11,15-18,20-21H,5-9H2,1-2H3/t11-,15-,16+,17+,18-,19+/s2; Key:DXWWYJWUFULMAP-BQXDHOISNA-N;

7α-甲基雌二醇（英语：7α-Methylestradiol，缩写7α-Me-E2，也称为7α-甲基雌甾-1,3,5(10)-三烯-3,17β-二醇，7α-methylestra-1,3,5(10)-triene-3,17β-diol）是一种人工合成的甾体类雌激素药物，对雌激素受体的亲和力与雌二醇相当^[2]。7α-甲基雌二醇同时也是雄激素/同化类固醇曲托龙的活性代谢产物，是曲托龙造成的雌激素效应的原因^[3]^[4]。

另见

^ Steroid with high estrogenic effect（法文）. 1965. FR 1418540.
^ Raynaud, J.P.; Ojasoo, T.; Bouton, M.M.; Philibert, D. Receptor Binding as a Tool in the Development of New Bioactive Steroids. Drug Design. 1979: 169–214 [2021-06-27]. ISBN 9780120603084. doi:10.1016/B978-0-12-060308-4.50010-X. （原始内容存档于2020-06-04）.
^ García-Becerra R, Ordaz-Rosado D, Noé G, Chávez B, Cooney AJ, Larrea F. Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated-transactivation. Reproduction. 2012, 143 (2): 211–9. PMID 22065861. doi:10.1530/REP-11-0171 .
^ Attardi BJ, Pham TC, Radler LC, Burgenson J, Hild SA, Reel JR. Dimethandrolone (7,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. The Journal of Steroid Biochemistry and Molecular Biology. June 2008, 110 (3–5): 214–22. PMC 2575079 . PMID 18555683. doi:10.1016/j.jsbmb.2007.11.009.