CpG寡脱氧核苷酸
CpG寡脱氧核苷酸（英语：CpG oligodeoxynucleotides，CpG ODN）是短的单链DNA分子，其序列包含一个胞嘧啶脱氧核苷酸 ("C")，紧接着一个 鸟嘌呤脱氧核苷酸 ("G")，"p"是指两者之间的磷酸二酯键链接。当CpG寡脱氧核苷酸处于未甲基化的状态时，可以作为免疫增强剂[1]。未甲基化的CpG ODN是一种病原相关分子模式，因为其在脊椎动物的基因组中很稀有，而在微生物的基因组中很丰富。[2]。CpG ODN是公认的模式识别受体（PRR）Toll样受9（TLR9）的配体，TLR9只在人类和其他较高的灵长类动物的B细胞和浆细胞样树突状细胞（pDC）中表达。[3]
参考文献
[编辑]- ^ Weiner, GJ; Liu, HM; Wooldridge, JE; Dahle, CE; Krieg, AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proceedings of the National Academy of Sciences of the United States of America. 1997, 94 (20): 10833–7. PMC 23500
. PMID 9380720. doi:10.1073/pnas.94.20.10833.
- ^ Bauer, S; Wagner, H. Bacterial CpG-DNA licenses TLR9. Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology. 2002, 270: 145–54. ISBN 978-3-642-63975-3. PMID 12467249. doi:10.1007/978-3-642-59430-4_9.
- ^ Rothenfusser, S; Tuma, E; Endres, S; Hartmann, G. Plasmacytoid dendritic cells: the key to CpG. Human immunology. 2002, 63 (12): 1111–9. PMID 12480254. doi:10.1016/S0198-8859(02)00749-8.
