鴨嘴花鹼酮

鴨嘴花鹼酮
	IUPAC名; (1S)-1-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-5(1H)-one
識別
CAS號	486-64-6
PubChem	442935
ChemSpider	391238
SMILES	C1CN2C(=NC3=CC=CC=C3C2=O)[C@H]1O;
ChEBI	9936
性質
化學式	C11H10N2O2
摩爾質量	202.21 g·mol−1
密度	1.5 g/cm3
熔點	200 - 202 °C（271 K）
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

鴨嘴花鹼酮（英語：Vasicinone）是一種喹唑啉生物鹼。它在體外顯示出支氣管擴張作用，^[1]但在體內顯示出支氣管收縮作用。^[2]鴨嘴花鹼酮被證明具有抗過敏作用。^[3]它是在駱駝蓬中發現的。^[4]

鴨嘴花鹼酮與類似物鴨嘴花鹼的組合也被進行了研究。兩種生物鹼的組合（1:1）在體內和體外均顯示出顯着的支氣管擴張活性。^[5]這兩種生物鹼也是呼吸興奮劑。^[5]鴨嘴花鹼具有心臟抑制作用，鴨嘴花鹼酮是一種弱心臟興奮劑；通過結合這兩種生物鹼可以使效果正常化。^[5]^[3]據報道，鴨嘴花鹼具有子宮興奮作用。^[3]

參考資料[編輯]

^ Amin, A. H.; Mehta, D. R. A Bronchodilator Alkaloid (Vasicinone) from Adhatoda vasica Nees. Nature. 1959, 184 (4695): 1317. Bibcode:1959Natur.184.1317A. ISSN 0028-0836. PMID 13793186. doi:10.1038/1841317a0 .
^ Mehta, D. R.; Naravane, J. S.; Desai, R. M. Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae). The Journal of Organic Chemistry. 1963, 28 (2): 445–448. ISSN 0022-3263. doi:10.1021/jo01037a041.
^ ^3.0 ^3.1 ^3.2 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058 . PMID 20390078. doi:10.4103/0250-474X.40329 .
^ Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998 . PMID 24347928. doi:10.4103/0973-7847.120524 .
^ ^5.0 ^5.1 ^5.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175.

[AminMehta1959-1] Amin, A. H.; Mehta, D. R. A Bronchodilator Alkaloid (Vasicinone) from Adhatoda vasica Nees. Nature. 1959, 184 (4695): 1317. Bibcode:1959Natur.184.1317A. ISSN 0028-0836. PMID 13793186. doi:10.1038/1841317a0 .

[MehtaNaravane1963-2] Mehta, D. R.; Naravane, J. S.; Desai, R. M. Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae). The Journal of Organic Chemistry. 1963, 28 (2): 445–448. ISSN 0022-3263. doi:10.1021/jo01037a041.

[RajaniSoni2008-3] 3.0 ^3.1 ^3.2 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058 . PMID 20390078. doi:10.4103/0250-474X.40329 .

[4] Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998 . PMID 24347928. doi:10.4103/0973-7847.120524 .

[avula2008-5] 5.0 ^5.1 ^5.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175.

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