局部場電位

局部場電位（英語：Local field potential，縮寫：LFP）是一類特殊的電生理信號。在生物體內，具有一定體積的生物組織中的樹突突觸活動會引發電流，當這股電流流經具有一定阻抗的細胞外空間時，就形成了一定的電壓分佈，在某一點記錄到的局部電壓值就叫做局部場電位。這個術語通常用於麻醉動物或者腦片的電生理研究中。

背景知識

使用低阻抗的微電極來對細胞進行胞外電生理記錄，然後進行低通濾波（截止頻率為300Hz），所獲得的數據可以使用電腦進行記錄與分析。沒有經過濾波的信號反映了電極尖端附近 50-350 μm 的動作電位的疊加情況^[1]^[2] 和電極尖端附近 0.5-3mm 的慢離子通道事件^[3]。信號經過低通濾波可以去除動作電位成分並得到低頻的局部場電位信號。

參考文獻

^ Legatt, A. D., Arezzo, J., & Vaughan, H. G. (1980). Averaged multiple unit activity as an estimate of phasic changes in local neuronal activity: effects of volume-conducted potentials. Journal of Neuroscience Methods, 2(2), 203-217.
^ Gray, C. M., Maldonado, P. E., Wilson, M., and McNaughton, B. (1995). Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex. Journal of Neuroscience Methods 63, 43–54.
^ Juergens, Egbert and Guettler, Andreas and Eckhorn, R. (1999). Visual stimulation elicits locked and induced gamma oscillations in monkey intracortical- and EEG-potentials, but not in human EEG. Experimental Brain Research 129, 247-259.

外部連結

局部電位(local potential) （頁面存檔備份，存於互聯網檔案館）

[1] Legatt, A. D., Arezzo, J., & Vaughan, H. G. (1980). Averaged multiple unit activity as an estimate of phasic changes in local neuronal activity: effects of volume-conducted potentials. Journal of Neuroscience Methods, 2(2), 203-217.

[2] Gray, C. M., Maldonado, P. E., Wilson, M., and McNaughton, B. (1995). Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex. Journal of Neuroscience Methods 63, 43–54.

[3] Juergens, Egbert and Guettler, Andreas and Eckhorn, R. (1999). Visual stimulation elicits locked and induced gamma oscillations in monkey intracortical- and EEG-potentials, but not in human EEG. Experimental Brain Research 129, 247-259.

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