Vero E6

Vero E6（亦称Vero C1008）是一种非洲绿猴肾细胞系，是Vero 76细胞衍生的克隆株，并且在形成单层膜后显示出一定程度的接触抑制（英语：Contact inhibition）作用，故而适合繁殖一些复制缓慢的病毒。当Vero E6细胞被马秋波病毒（Machupo virus）、胡宁病毒（英语：Argentinian mammarenavirus）及拉萨病毒（英语：Lassa mammarenavirus）等出血热病毒、马尔堡病毒或萨伊埃博拉病毒等病毒感染时，都会表现出细胞病变作用。该细胞系目前已进一步用于麻疹病毒^[1]、埃博拉病毒^[2]、克里米亚-刚果出血热病毒^[3]、严重急性呼吸系统综合症冠状病毒^[4]及严重急性呼吸系统综合症冠状病毒2型（SARS-CoV-2）^[5]等的分离和生长。

细胞系[编辑]

Vero细胞
- Vero 76
  - Vero E6
    - sVero p66
    - Vero E6-S

参考资料[编辑]

^ Rota, JS; Hummel, KB; Rota, PA; Bellini, WJ. Genetic variability of the glycoprotein genes of current wild-type measles isolates.. Virology. 1992-05, 188 (1): 135–42 [2020-02-22]. PMID 1566568. doi:10.1016/0042-6822(92)90742-8. （原始内容存档于2020-02-22）.
^ Sanchez, A; Kiley, MP. Identification and analysis of Ebola virus messenger RNA.. Virology. 1987-04, 157 (2): 414–20 [2020-02-22]. PMID 2881398. doi:10.1016/0042-6822(87)90283-2. （原始内容存档于2020-02-22）.
^ Saijo, M; Qing, T; Niikura, M; Maeda, A; Ikegami, T; Prehaud, C; Kurane, I; Morikawa, S. Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus.. Journal of clinical microbiology. 2002-05, 40 (5): 1587–91 [2020-02-22]. PMID 11980926. doi:10.1128/jcm.40.5.1587-1591.2002. （原始内容存档于2020-02-22）.
^ Ng, ML; Tan, SH; See, EE; Ooi, EE; Ling, AE. Proliferative growth of SARS coronavirus in Vero E6 cells.. The Journal of general virology. 2003-12, 84 (Pt 12): 3291–303 [2020-02-22]. PMID 14645910. doi:10.1099/vir.0.19505-0. （原始内容存档于2020-02-22）.
^ Wang, Manli; Cao, Ruiyuan; Zhang, Leike; Yang, Xinglou; Liu, Jia; Xu, Mingyue; Shi, Zhengli; Hu, Zhihong; Zhong, Wu; Xiao, Gengfu. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020-02-04 [2020-02-22]. doi:10.1038/s41422-020-0282-0. （原始内容存档于2020-02-22）.

[1] Rota, JS; Hummel, KB; Rota, PA; Bellini, WJ. Genetic variability of the glycoprotein genes of current wild-type measles isolates.. Virology. 1992-05, 188 (1): 135–42 [2020-02-22]. PMID 1566568. doi:10.1016/0042-6822(92)90742-8. （原始内容存档于2020-02-22）.

[2] Sanchez, A; Kiley, MP. Identification and analysis of Ebola virus messenger RNA.. Virology. 1987-04, 157 (2): 414–20 [2020-02-22]. PMID 2881398. doi:10.1016/0042-6822(87)90283-2. （原始内容存档于2020-02-22）.

[3] Saijo, M; Qing, T; Niikura, M; Maeda, A; Ikegami, T; Prehaud, C; Kurane, I; Morikawa, S. Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus.. Journal of clinical microbiology. 2002-05, 40 (5): 1587–91 [2020-02-22]. PMID 11980926. doi:10.1128/jcm.40.5.1587-1591.2002. （原始内容存档于2020-02-22）.

[4] Ng, ML; Tan, SH; See, EE; Ooi, EE; Ling, AE. Proliferative growth of SARS coronavirus in Vero E6 cells.. The Journal of general virology. 2003-12, 84 (Pt 12): 3291–303 [2020-02-22]. PMID 14645910. doi:10.1099/vir.0.19505-0. （原始内容存档于2020-02-22）.

[5] Wang, Manli; Cao, Ruiyuan; Zhang, Leike; Yang, Xinglou; Liu, Jia; Xu, Mingyue; Shi, Zhengli; Hu, Zhihong; Zhong, Wu; Xiao, Gengfu. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020-02-04 [2020-02-22]. doi:10.1038/s41422-020-0282-0. （原始内容存档于2020-02-22）.

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