肺炎球菌多糖疫苗

肺炎球菌多糖疫苗
疫苗說明
目標	23 serotypes of Streptococcus pneumoniae
種類	多醣體
臨床資料
商品名（英語：Drug nomenclature）	Pneumovax 23
AHFS/Drugs.com	Monograph
MedlinePlus	a607022
懷孕分級	澳: B2 ; ;
給藥途徑	Intramuscular injection (IM)
ATC碼	J07AL01 (WHO) ;
法律規範狀態
法律規範	美：處方藥（℞-only）;
識別資訊
CAS號	2158248-63-4
ChemSpider	none;

肺炎球菌多糖疫苗（Pneumococcal polysaccharide vaccine，PPSV）又稱23價肺炎球菌疫苗（Pneumovax 23，PPV-23），是第一個從莢膜多糖中提取的肺炎鏈球菌疫苗。多糖抗原被用來誘導特定類型的抗體，這些抗體可以增強吞噬免疫細胞對肺炎鏈球菌（肺炎球菌）的殺傷力。不少高風險的成年人已接種肺炎球菌多糖疫苗^[2]。因此，侵襲性肺炎球菌病的發病率和死亡率都有所降低。

該疫苗最初為四價疫苗，於1945年首次使用^[3]。1983年，疫苗改進為23價疫苗（PPSV23）。2000年2月開始，蛋白結合七價疫苗(PCV7)許可證頒發^[4]。

參考文獻

^ ^1.0 ^1.1 Pneumococcal 23-polyvalent vaccine (Pneumovax 23) Use During Pregnancy. Drugs.com. 7 October 2019 [14 July 2020]. （原始內容存檔於2021-05-14）.
^ The persisting burden of invasive pneumococcal disease in HIV patients: an observational cohort study. BMC Infectious Diseases. November 2011, 11: 314. PMC 3226630 . PMID 22078162. doi:10.1186/1471-2334-11-314.
^ Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J Exp Med. 1945, 82 (6): 445–65. PMC 2135567 . PMID 19871511. doi:10.1084/jem.82.6.445.
^ Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children. Vaccine. 2007, 25 (45): 7858–65. PMID 17931753. doi:10.1016/j.vaccine.2007.08.022.

[Drugs.com_pregnancy-1] 1.0 ^1.1 Pneumococcal 23-polyvalent vaccine (Pneumovax 23) Use During Pregnancy. Drugs.com. 7 October 2019 [14 July 2020]. （原始內容存檔於2021-05-14）.

[Siemieniuk_2011-2] The persisting burden of invasive pneumococcal disease in HIV patients: an observational cohort study. BMC Infectious Diseases. November 2011, 11: 314. PMC 3226630 . PMID 22078162. doi:10.1186/1471-2334-11-314.

[3] Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J Exp Med. 1945, 82 (6): 445–65. PMC 2135567 . PMID 19871511. doi:10.1084/jem.82.6.445.

[pmid17931753-4] Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children. Vaccine. 2007, 25 (45): 7858–65. PMID 17931753. doi:10.1016/j.vaccine.2007.08.022.

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