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奥贝胆酸

维基百科,自由的百科全书
奥贝胆酸
臨床資料
商品名英语Drug nomenclatureOcaliva
其他名稱6α-ethyl-chenodeoxycholic acid; INT-747
AHFS/Drugs.comocaliva
MedlinePlusa616033
核准狀況
给药途径口服给药
ATC碼
法律規範狀態
法律規範
识别信息
  • (3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic acid

    OR

    (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS号459789-99-2
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.238.318 編輯維基數據鏈接
化学信息
化学式C26H44O4
摩尔质量420.62516 g/mol
3D模型(JSmol英语JSmol
熔点108—110 °C(226—230 °F) [1]
  • CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O
  • InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
  • Key:ZXERDUOLZKYMJM-ZWECCWDJSA-N

奥贝胆酸(英語:Obeticholic acid,缩写OCA,也叫做6α-乙基-鹅去氧胆酸,6α-ethyl-chenodeoxycholic acid,商品名Ocaliva)是一种半合成胆汁酸,用于治疗原发性胆汁性胆管炎,后又用于治疗几种肝病大日本住友製藥拥有此药在中国和日本的所有权[2]

参考文献

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  1. ^ Gioiello, Antimo; Macchiarulo, Antonio; Carotti, Andrea; Filipponi, Paolo; Costantino, Gabriele; Rizzo, Giovanni; Adorini, Luciano; Pellicciari, Roberto. Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry. April 2011, 19 (8): 2650–2658. PMID 21459580. doi:10.1016/j.bmc.2011.03.004. 
  2. ^ Wall Street Journal. A $4 Billion Surprise for 45-Person Biotech. [10 January 2014]. (原始内容存档于2014-03-28). 

外部链接

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