CpG寡脱氧核苷酸：修订间差异

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2017年4月15日 (六) 05:05的版本

CpG寡脱氧核苷酸 (CpG oligodeoxynucleotides，CpG ODN)是短的单链合成的 DNA 分子，包含一个胞嘧啶磷酸脱氧核苷酸 ("C")，其次是一个鸟嘌呤三磷酸脱氧核苷酸 ("G"). "P"是指磷酸二酯之间的链接，连续的核苷酸，尽管有些光有一个修改磷酸酯 (PS)骨干，而不是。当这些央人民政府主题是非甲基化，他们的行为作为免疫增强剂.^[1] 消费品的图案被认为病原体有关的分子模式(原)由于其丰富的微生物基因组，但他们的稀有脊椎动物的基因组。^[2] 的消费品辛夷是公认的模式识别受体(PRR)Toll样受9(TLR9)，这是一表示只有在 B细胞和浆细胞样的树枝状细胞 (pdc)在人类和其他较高的灵长类动物。^[3]

参考文献

^ Weiner, GJ; Liu, HM; Wooldridge, JE; Dahle, CE; Krieg, AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proceedings of the National Academy of Sciences of the United States of America. 1997, 94 (20): 10833–7. PMC 23500 . PMID 9380720. doi:10.1073/pnas.94.20.10833.
^ Bauer, S; Wagner, H. Bacterial CpG-DNA licenses TLR9. Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology. 2002, 270: 145–54. ISBN 978-3-642-63975-3. PMID 12467249. doi:10.1007/978-3-642-59430-4_9.
^ Rothenfusser, S; Tuma, E; Endres, S; Hartmann, G. Plasmacytoid dendritic cells: the key to CpG. Human immunology. 2002, 63 (12): 1111–9. PMID 12480254. doi:10.1016/S0198-8859(02)00749-8.

[pmid9380720-1] Weiner, GJ; Liu, HM; Wooldridge, JE; Dahle, CE; Krieg, AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proceedings of the National Academy of Sciences of the United States of America. 1997, 94 (20): 10833–7. PMC 23500 . PMID 9380720. doi:10.1073/pnas.94.20.10833.

[Bacterial_CpG-DNA_licenses_TLR9-2] Bauer, S; Wagner, H. Bacterial CpG-DNA licenses TLR9. Current topics in microbiology and immunology. Current Topics in Microbiology and Immunology. 2002, 270: 145–54. ISBN 978-3-642-63975-3. PMID 12467249. doi:10.1007/978-3-642-59430-4_9.

[pmid12480254-3] Rothenfusser, S; Tuma, E; Endres, S; Hartmann, G. Plasmacytoid dendritic cells: the key to CpG. Human immunology. 2002, 63 (12): 1111–9. PMID 12480254. doi:10.1016/S0198-8859(02)00749-8.

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